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The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation

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Abstract

Ca2+ signaling in T-lymphocytes involves Ca2+ release from intracellular stores as well as Ca2+entry from the extracellular space [reviewed in 1–3]. Ten years ago many researchers believed that Ca2+ release in T cells is exclusively operated by D-myo-inositol 1,4,5-trisphosphate (InsP3; reviewed in ref. 4) while the capacitative mechanism of Ca2+ entry proposed by Putney [5] was thought to play a central role in the influx process.

Keywords

Nicotinamide Adenine Dinucleotide Phosphate Nicotinic Acid Adenine Dinucleotide Phosphate Sustained Phase Ryanodine Binding Single Cell Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  1. 1.Institute for Medical Biochemistry and Molecular Biology, Division of Cellular Signal TransductionUniversity Hospital Hamburg-EppendorfHamburgGermany

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