The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation



Ca2+ signaling in T-lymphocytes involves Ca2+ release from intracellular stores as well as Ca2+entry from the extracellular space [reviewed in 1–3]. Ten years ago many researchers believed that Ca2+ release in T cells is exclusively operated by D-myo-inositol 1,4,5-trisphosphate (InsP3; reviewed in ref. 4) while the capacitative mechanism of Ca2+ entry proposed by Putney [5] was thought to play a central role in the influx process.


Nicotinamide Adenine Dinucleotide Phosphate Nicotinic Acid Adenine Dinucleotide Phosphate Sustained Phase Ryanodine Binding Single Cell Imaging 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  1. 1.Institute for Medical Biochemistry and Molecular Biology, Division of Cellular Signal TransductionUniversity Hospital Hamburg-EppendorfHamburgGermany

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