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The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation

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Cyclic ADP-Ribose and NAADP

Abstract

Ca2+ signaling in T-lymphocytes involves Ca2+ release from intracellular stores as well as Ca2+entry from the extracellular space [reviewed in 1–3]. Ten years ago many researchers believed that Ca2+ release in T cells is exclusively operated by D-myo-inositol 1,4,5-trisphosphate (InsP3; reviewed in ref. 4) while the capacitative mechanism of Ca2+ entry proposed by Putney [5] was thought to play a central role in the influx process.

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Author information

Authors and Affiliations

  1. Institute for Medical Biochemistry and Molecular Biology, Division of Cellular Signal Transduction, University Hospital Hamburg-Eppendorf, Martinistr. 52, D-20246, Hamburg, Germany

    Andreas H. Guse

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  1. Andreas H. Guse
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  1. Minneapolis, USA

    Hon Cheung Lee

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Guse, A.H. (2002). The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation. In: Lee, H.C. (eds) Cyclic ADP-Ribose and NAADP. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0269-2_14

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  • DOI: https://doi.org/10.1007/978-1-4615-0269-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4996-9

  • Online ISBN: 978-1-4615-0269-2

  • eBook Packages: Springer Book Archive

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