Alteration of energy production by the heart in CRF patients undergoing peritoneal dialysis
Cardiovascular disease is commonly observed in patients with chronic renal failure and this is a leading cause of death in patients with end-stage renal disease undergoing maintenance dialysis. Myocardial energy production is a very crucial aspect of cardiac function. Therefore, to evaluate energy metabolism of myocardial muscle in peritoneal dialysis (PD) patients, we carried out the following study using Magnetic resonance spectroscopy (MRS).
Fourteen chronic renal failure patients and eight healthy volunteers were enrolled. The ratio of the phosphocreatine peak to the beta-phosphate to ATP peak (PCr/ß-ATP) was calculated from their MR spectra obtained by31P-MR spectroscopy (Gyroscan S15, Philips). To determine the correlation between cardiac function and energy status, the left atrial diameter, the left ventricular (LV) end-diastolic diameter, the ejection fraction, the fraction of shortening and the LV mass index were measured by echocardiography. Peripheral blood sampling was also performed for creatinine, blood urea nitrogen, hematocrit, hemoglobin, ß2microglobuline, intact parathyroid hormone.
PCr/ß-ATP was significantly lower in PD (1.03 ± 0.15 vs. 1.40 ± 0.18: p = 0.0002), although all patients showed normal systolic function. No correlation was found between PCr/ß-ATP and cardiac function or hematological or biochemical markers. A negative correlation was present between PCr/f3-ATP and dialysis duration (r = 0.57, p < 0.05).
Altered energy status of the myocardium in PD should be considered even if the patients did not show any systolic dysfunction.31P-MRS is a useful tool to evaluate the energy status of the myocardium. (Mol Cell Biochem 244: 135-138, 2003)
Key wordsenergy metabolism chronic renal failure myocardium magnetic resonance spectroscopy
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