Function of PACAP in the Respiratory System
Since the discovery of the activity of vasoactive intestinal peptide (VIP) as a vasodilator peptide in the lung (Said, 1967) and its subsequent isolation from the small intestine (Said and Mutt, 1970), a rich array of studies has characterized the presence and/or the regulatory role of many other neuropeptides in the respiratory system (Boonsma and Said, 1992; Said, 1995; Maggi et al, 1995; Van der Velden et al, 1999). The observation of the potent anti-asthma and anti-inflammatory effects of VIP in the lung and airways was confirmed with other VIP-related peptides that possess common mechanisms of action (Said, 1992; Maggi et al, 1995).
KeywordsVasoactive Intestinal Peptide Airway Smooth Muscle Vasoactive Intestinal Polypeptide Pituitary Adenylate Cyclase Activate Polypeptide Small Cell Lung Cancer Cell
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