Dysfunctional Microvascular Conducted Response in Irradiated Normal Tissue
Ionizing radiation is used widely to treat many conditions including cancer, arteriovenous malformations (AVM), macular degeneration, and intimai hyperplasia. Damage to the microvasculature constitutes one of the most important components of the late effects of radiation damage to many organs in clinical applications. While the effects of ionizing radiation on microvascular structure and function of normal tissue have been studied, the mechanisms by which ionizing radiation interferes with the normal microvascular control processes are not well understood. An important question is why normal microvasculature is not able to repair radiation damage as efficiently as it is able to repair other forms of damage (e.g. wounds). Understanding the mechanisms by which ionizing radiation damages the microvasculature has important clinical implications.
KeywordsIschemia Adenosine Bicarbonate Norepinephrine Epinephrine
Unable to display preview. Download preview PDF.
- 1.Rubin P: Clinical Oncology. Philadelphia, PA, W.B. Saunders Company, 1993.Google Scholar
- 15.Bird RB, Stewart WE, Lightfoot EN: Concentration Distributions in Solids and in Laminar Flow (Transport Phenomena, Bird, Stewart, Lightfoot, eds). New York, John Wiley & Sons, pp519–553, 1960.Google Scholar
- 17.Kiani, M. F. Mathematical modeling of microvascular growth and adaptation. Ph.D. Dissertation, Louisiana Tech University, Ruston, LA, 1990.Google Scholar
- 21.Xia J, Little TL, Duling BR: Cellular pathways of the conducted electrical response in arterioles of hamster cheek pouch in vitro. Am.J.Physiol. 269: H203I-H2038, 1995.Google Scholar