Dysfunctional Microvascular Conducted Response in Irradiated Normal Tissue
Ionizing radiation is used widely to treat many conditions including cancer, arteriovenous malformations (AVM), macular degeneration, and intimai hyperplasia. Damage to the microvasculature constitutes one of the most important components of the late effects of radiation damage to many organs in clinical applications. While the effects of ionizing radiation on microvascular structure and function of normal tissue have been studied, the mechanisms by which ionizing radiation interferes with the normal microvascular control processes are not well understood. An important question is why normal microvasculature is not able to repair radiation damage as efficiently as it is able to repair other forms of damage (e.g. wounds). Understanding the mechanisms by which ionizing radiation damages the microvasculature has important clinical implications.
KeywordsVasodilatory Response Vasoactive Agent Selective Blocker Microvascular Network Cremaster Muscle
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