Physiology of Functional Activation

  • John A. Detre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 510)


Nearly all studies of task-specific activation using functional neuroimaging rely on the existence of a close coupling between regional changes in brain metabolism and regional cerebral blood flow (CBF), herein referred to as activation-flow coupling (AFC). Regional CBF changes are used as a surrogate marker for changes in regional brain function, and uncoupling of blood flow and metabolism or neuronal function may result in false negative or false positive activation. Changes in blood flow and metabolism occur with excitatory or inhibitory neurotransmission, both of which are energy consuming processes.


Cerebral Blood Flow Functional Magnetic Resonance Imaging Blood Oxygenation Level Dependent Arterial Spin Label Blood Oxygenation Level Dependent Signal 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • John A. Detre
    • 1
  1. 1.Department of NeurologyUniversity of Pennsylvania School of MedicinePhiladelphia

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