Effect of Hydralazine on Blood Flow, Oxygenation, and Interstitial Fluid Pressure in Subcutaneous Tumors

  • Tomaž Jarm
  • Blaž Podobnik
  • Damijan Miklavčič
  • Gregor Serša
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 510)


Many experimental and clinical solid tumors are known to exhibit poor oxygenation and high interstitial fluid pressure (IFP) in comparison to normal surrounding tissues. Oxygenation and IFP in addition to abnormal blood flow influence the response of tumors to various therapies and are also important for development and progression of malignant growth.“ Hydralazine (HYZ) is an arteriolar vasodilating drug which is used for treatment of hypertension in humans. HYZ can decrease both tumor blood flow and tumor IFP. These two changes may have opposite effects on drug delivery and oxygenation in tumors. In our study we evaluated the effect of HYZ on blood flow, oxygenation, and IFP in a murine tumor model. Oxygenation was measured by a relatively new method which has recently become available, the OxyLite system.


Laser Doppler Flowmetry Interstitial Fluid Pressure Tumor Blood Flow Tumor Oxygenation Abnormal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Tomaž Jarm
    • 1
  • Blaž Podobnik
    • 1
  • Damijan Miklavčič
    • 1
  • Gregor Serša
    • 2
  1. 1.Faculty of Electrical EngineeringUniversity of LjubljanaLjubljanaSlovenia
  2. 2.Institute of OncologyLjubljanaSlovenia

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