Oxygen Transport To Tissue XXIII pp 57-61 | Cite as
Lack of Association Between Tumor Hypoxia, Glut-1 Expression and Glucose Uptake in Experimental Sarcomas
Chapter
- 3 Citations
- 283 Downloads
Abstract
Hypoxia is a common phenomenon in experimental and human tumors which not only limits the efficacy of non-surgical treatment modalities such as irradiation and 02-dependent chemotherapy but also affects the long-term prognosis of cancer patients. Numerous studies have clearly demonstrated that patients with more hypoxic tumors have a reduced probability for survival and disease-free survival’. For this reason it might be helpful to non-invasively identify patients with hypoxic malignancies.
Keywords
Positron Emission Tomography Tumor Hypoxia Increase Tumor Volume Cellular Glucose Uptake High Glycolytic Rate
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- 1.M. Höckel and P. Vaupel, Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsJ.Natl. Cancer Inst. 93266–276 (2001).PubMedCrossRefGoogle Scholar
- 2.R. Airley, J. Loncaster, S. Davidson, M. Bromley, S. Roberts, A. Patterson, R. Hunter, I. Stratford, and C. West, Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervixClin.Cancer Res.7, 928–934 (2001).PubMedGoogle Scholar
- 3.D.K. Kelleher, O. Thews, and P. Vaupel, Hypoxyradiotherapy: lack of experimental evidence for a preferential radioprotective effect on normal versus tumor tissue as shown by direct oxygenation measurements in experimental sarcomasRadiother.Oncol. 45191–197 (1997).PubMedCrossRefGoogle Scholar
- 4.E.K. Pauwels, M.J. Ribeiro, J.H. Stoot, V.R. McCready, M. Bourguignon, and B. Maziere, FDG accumulation and tumor biologyNucl.Med.Biol. 25317–322 (1998).PubMedCrossRefGoogle Scholar
- 5.S. Egert, N. Nguyen, F.C. Brosius, III, and M. Schwaiger, Effects of wortmannin on insulin-and ischemiainduced stimulation of GLUT4 translocation and FDG uptake in perfused rat heartsCardiovasc.Res. 35283–293 (1997).PubMedCrossRefGoogle Scholar
- 6.P. Burgman, J.A. Odonoghue, J.L. Humm, and C.C. Ling, Hypoxia-induced increase in FDG uptake in MCF7 cellsJ.Nucl.Med. 42170–175 (2001).PubMedGoogle Scholar
- 7.A.C. Clavo, R.S. Brown, and R.L. Wahl, Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxiaJ.Nucl.Med.36, 1625–1632 (1995).PubMedGoogle Scholar
- 8.H. Minn, A.C. Clavo, and R.L. Wahl, Influence of hypoxia on tracer accumulation in squamous-cell carcinoma:in vitroevaluation for PET imagingNucl.Med.Biol. 23941–946 (1996).PubMedCrossRefGoogle Scholar
- 9.K. Dhital, C.A. Saunders, P.T. Seed, M.J. O’Doherty, and J. Dussek, [18F]Fluorodeoxyglucose positron emission tomography and its prognostic value in lung cancerEur.J.Cardiothorac.Surg.18,425–428 (2000).PubMedCrossRefGoogle Scholar
- 10.B. Nakata, Y.S. Chung, S. Nishimura, T. Nishihara, Y. Sakurai, T. Sawada, T. Okamura, J. Kawabe, H. Ochi, and M. Sowa18F-Fluorodeoxyglucose positron emission tomography and the prognosis of patients with pancreatic adenocarcinomaCancer 79695–699 (1997).PubMedCrossRefGoogle Scholar
- 11.M. Oshida, K. Uno, M. Suzuki, T. Nagashima, H. Hashimoto, H. Yagata, T. Shishikura, K. Imazeki, and N. Nakajima, Predicting the prognoses of breast carcinoma patients with positron emission tomography using 2-deoxy-2-fluoro[18F]-D-glucoseCancer 822227–2234 (1998).PubMedCrossRefGoogle Scholar
Copyright information
© Springer Science+Business Media New York 2003