Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma

  • Shuntaro Hara
  • Yukihiro Kondo
  • Ichiro Matsuzawa
  • Yoshitaka Hashimoto
  • Go Kimura
  • Masaso Akimoto
  • Nobumasa Imura
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Cyclooxygenase (COX) catalyses the synthesis of prostaglandins from arachidonic acid. There are two isoforms of COX (DuBois et al., 1998; vane et al., 1998). One is constitutively expressed (COX-1) and the other is inducible (COX-2). The COX-2 gene is an immediate, early-response gene that is induced by growth factors, oncogenes, carcinogens, and tumor-promoting phorbol esters (Inoue et al., 1995; Nanayama et al., 1995; Herschman, 1996). The constitutive isoform, COX-1, is essentially unaffected by these factors.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Shuntaro Hara
    • 1
  • Yukihiro Kondo
    • 2
  • Ichiro Matsuzawa
    • 2
  • Yoshitaka Hashimoto
    • 2
  • Go Kimura
    • 2
  • Masaso Akimoto
    • 2
  • Nobumasa Imura
    • 1
  1. 1.School of Pharmaceutical SciencesKitasato UniversityTokyoJapan
  2. 2.Nippon Medical SchoolKitasato UniversityTokyoJapan

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