Abstract
Cyclooxygenase (COX) catalyses the synthesis of prostaglandins from arachidonic acid. There are two isoforms of COX (DuBois et al., 1998; vane et al., 1998). One is constitutively expressed (COX-1) and the other is inducible (COX-2). The COX-2 gene is an immediate, early-response gene that is induced by growth factors, oncogenes, carcinogens, and tumor-promoting phorbol esters (Inoue et al., 1995; Nanayama et al., 1995; Herschman, 1996). The constitutive isoform, COX-1, is essentially unaffected by these factors.
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Hara, S. et al. (2002). Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_20
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DOI: https://doi.org/10.1007/978-1-4615-0193-0_20
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