The Role of Striatal Adenosine A2A Receptors in Motor Control of Rats

  • Wolfgang Hauber
  • Jens Nagel
  • Partic Neuscheler
  • Michael Koch
Part of the Advances in Behavioral Biology book series (ABBI, volume 54)


It is well known that adenosine and ATP play a central role in the energy metabolism of all organisms. However, adenosine is also an important endogenous modulator which is involved in the regulation of numerous physiological processes. It is released in part from metabolically active cells by facilitated diffusion. In addition, adenosine is generated in the extracellular space by rapid and quantitative ectoenzymatic degradation of released ATP.1


Nucleus Accumbens Prepulse Inhibition Sensorimotor Gating Entopeduncular Nucleus Striatopallidal Neuron 
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  1. 1.
    Linden, J.Purinergic systems in Basic NeurochemistryGJ. Siegelet al.Editors. 1994, Raven Press: New York. p. 401–416.Google Scholar
  2. 2.
    Rivkees, S.A., S.L. Price, and F.C. Zhou, Immunohistochemical detection of Al receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum and basal gangliaBrain Res.677 (1995) 193–203.PubMedCrossRefGoogle Scholar
  3. 3.
    Ongini, E. and B.B. Fredholm, Pharmacology of adenosine A2a receptorsTrends Pharmacol. Sci.17 (1996) 364–372.PubMedGoogle Scholar
  4. 4.
    Ferré, S., B.B. Fredholm, M. Morelli, P. Popoli, and K. Fuxe, Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal gangliaTrends Neurosci.20 (1997) 482–487.PubMedCrossRefGoogle Scholar
  5. 5.
    Casas, M., S. Ferre, T. Guix, and F. Jane, Theophylline reverses haloperidol-induced catalepsy in therat Biol. Psychiatr.24 (1988) 642.CrossRefGoogle Scholar
  6. 6.
    Nagel, J. and W. HauberAdenosine differentially modulates motor behaviour mediated by striatal dopamine D1 and D2 receptorsinNew Neuroethology on the moveN. Elsner and R. Wehner, Editors. 1998, Thieme: Stuttgart. p. 68.Google Scholar
  7. 7.
    Müller, C.E., R. Sauer, Y. Maurish, R. Huertas, F. Fülle, K.-N. Klotz, J. Nagel, and W. Hauber, A2Aselective adensoine receptor antagonists: Development of water-soluble prodrugs and new tritiated radioligandsDrug Dey. Res.45 (1998) 190–197.CrossRefGoogle Scholar
  8. 8.
    Hauber, W., J. Nagel, R. Sauer, and C.E. Müller, Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamenNeuroreport9 (1998) 1803–1806.PubMedCrossRefGoogle Scholar
  9. 9.
    Hauber, W. and M. Münkle, Stimulation of adenosine A2a receptors in the rat striatum induces catalepsy that is reversed by antagonists of N-methy-D-aspartate receptorsNeurosci. Lett.196 (1995) 205–208.PubMedCrossRefGoogle Scholar
  10. 10.
    Fuxe, K., S. Ferre, M. Zoli, and L.F. Agnati, Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A(2A) dopamine D-2 and adenosine A(1) dopamine D-1 receptor interactions in the basal gangliaBrain Res. Rev.26 (1998) 258–273.PubMedCrossRefGoogle Scholar
  11. 11.
    Ferré, S., G Von Euler, B. Johansson, B.B. Fredholm, and K. Fuxe, Stimulation of high-affinity adenosine A2 receptors decreases the affinity of dopamine D2 receptors in rat striatal membranesProc. Natl. Acad. Sci. USA88 (1991) 7238–7241.PubMedCrossRefGoogle Scholar
  12. 12.
    Mori, A., T. Shindou, M. Ichimura, H. Nonaka, and H. Kase, The role of adenosine A2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neuronsJ. Neurosci.16 (1996) 605–611.PubMedGoogle Scholar
  13. 13.
    Richardson, P.J., H. Kase, and P. Jenner, Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson’s diseaseTrends Pharmacol. Sci. 18(1997) 338–344.PubMedGoogle Scholar
  14. 14.
    Rosin, D.I., A. Robeva, R.I. Woodard, P.G. Guyenet, and J. Linden, Immunohistochemical localization of adenosine A2A receptors in the rat central nervous systemJ. Comp. Neurol.401 (1998) 163–186.PubMedCrossRefGoogle Scholar
  15. 15.
    Fredholm, B.B. and P. Svenningsson, Striatal adenosine receptors-where are they? What do they do?Trends Pharmacol. Sci.19 (1998) 46–47.PubMedCrossRefGoogle Scholar
  16. 16.
    Kanda, T., S. Shiozaki, J. Shimada, F. Suzuki, and J. Nakamura, KF17837: a novel selective adenosine A(2A) receptor antagonist with anticataleptic activityEur. J. Pharmacol.256 (1994) 263.PubMedCrossRefGoogle Scholar
  17. 17.
    Morelli, M., S. Fenu, A. Pinna, and G. Di Chiara, Adenosine A(2) receptors interact negatively with dopamine D-1 and D-2 receptors in unilaterally 6-hydroxydopamine-lesioned ratsEur. J. Pharmacol.251 (1994) 21–25.PubMedCrossRefGoogle Scholar
  18. 18.
    Kanda, T., T. Tashiro, Y. Kuwana, and P. Jenner, Adenosine A(2A) receptors modify motor function in MPTP-treated common marmosetsNeuroreport9 (1998) 2857–2860.PubMedCrossRefGoogle Scholar
  19. 19.
    Mally, J. and T.W. Stone, The effect of theophylline on parkinson symptomsJ. Pharm. Pharmacol.46 (1994) 515–518.PubMedCrossRefGoogle Scholar
  20. 20.
    Barraco, R.A., K.A. Martens, M. Parizon, and H.J. Normile, Role of adenosine A2a receptors in the nucleus accumbensProg. Neuropsychopharm. Biol. Psychiatr.18 (1994) 545–549.CrossRefGoogle Scholar
  21. 21.
    Hauber, W. and M. Winkle, Motor depressant effects mediated by dopamine D2 and adenosine A2a receptors in the nucleus accumbens and the caudate-putamenEur. J. Pharmacol.323 (1997) 127–131PubMedCrossRefGoogle Scholar
  22. 22.
    Groenewegen, H.J., C.I. Wright, and A.V.J. BeijerThe nucleus accumbens: Gateway for limbic structures to reach the motor system?inEmotional Motor SystemG Holstege, R. Bandler, and C.B. Saper, Editors. 1996, Elsevier Science Pub.: 1000 AE Amsterdam. p. 485–511.CrossRefGoogle Scholar
  23. 23.
    Koch, M., The neurobiology of startle.Progr. Neurobiol.56 (1999) 1–22.Google Scholar
  24. 24.
    Koch, M. and W. Hauber, Regulation of sensorimotor gating by interactions of dopamine and adenosine in the ratBehay. Pharmacol.9 (1998) 23–29.Google Scholar
  25. 25.
    Hauber, W and M. Koch, Adenosine A2a receptors in the nucleus accumbens modulate prepulse inhibition of the startle responseNeuroreport8 (1997) 1515–1518.PubMedCrossRefGoogle Scholar
  26. 26.
    Swerdlow, N.R., D.L. Braff, N. Taaid, and M.A. Geyer, Assessing the validity of an animal model of deficient sensorimotor gating in Schizophrenic patientsArch. Gen. Psychiatry51 (1994) 139–154.PubMedCrossRefGoogle Scholar
  27. 27.
    Ferré, S., Adenosine-dopamine interactions in the ventral striatum. Implications for the treatment of schizophreniaPsychopharmacology133 (1997) 107–120.PubMedCrossRefGoogle Scholar
  28. 28.
    Lidow, M.S., GV. Williams, and P.S. Goldman-Rakic, The cerebral cortex: a case for a common site of action of antipsychotics.Trends. Pharmacol. Sci.19 (1998) 136–140.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Wolfgang Hauber
    • 1
  • Jens Nagel
    • 1
  • Partic Neuscheler
    • 1
  • Michael Koch
    • 2
  1. 1.Department of Animal PhysiologyUniversity of StuttgartStuttgartGermany
  2. 2.Department NeuropharmacologyUniversity of BremenBremenGermany

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