Abstract
Antisense riboprobes to preproenkephalin (PPE) mRNA reveal that a population of neurons within rodent globus pallidus (GP) contains this sequence. Colocalization studies indicate that the neurons expressing PPE mRNA are almost entirely (>97%) distinct from those immunoreactive for parvalbumin (PV). These two neuron populations differ in their axonal projections. A majority of the PPE mRNA-expressing pallidal neurons are retrogradely labeled following FluoroGold (FG) iontophoresis into the striatum, whereas a small minority are labeled following FG iontophoresis into the subthalamic nucleus (STN). By contrast, our previous work showed that most PV immunoreactive GP neurons are retrogradely labeled following STN FG iontophoresis, while a small minority are labeled by striatal FG deposits.
The integrity of the mesostriatal dopaminergic pathway contributes to regulating PPE mRNA expression within GP neurons. Rats with 6-hydroxydopamine injections along this pathway have greater PPE mRNA labeling per cell ipsilateral to the neurotoxin injection than in the unlesioned hemisphere.
Our previous work showed that the control of the immediate early gene, c-fos, within these GP neuron populations may differ. Whereas administration of dopamine D1/D2 receptor agonists induced Fos immunoreactivity in GP neurons irrespective of their PV content or the locus of their axonal projections, administration of the D2 receptor antagonist, eticlopride, induced Fos only in pallidostriatal neurons lacking PV immunoreactivity. These results suggest that the PV-containing and PPE-expressing pallidal neuron subpopulations are subject to differing controls by dopamine receptors.
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Marshall, J.F., Hoover, B.R., Schuller, J.J. (2002). The Enkephalin-Expressing Cells of the Rodent Globus Pallidus. In: Graybiel, A.M., Delong, M.R., Kitai, S.T. (eds) The Basal Ganglia VI. Advances in Behavioral Biology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0179-4_42
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DOI: https://doi.org/10.1007/978-1-4615-0179-4_42
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