Abstract
To determine the degree of coincidence of patch-matrix boundaries in the rat striatum identified by several markers, we performed immunocytochemistry on adjacent 40 µm sections, using antibodies to the mu opiate receptor (MOR), somatostatin-28 and calbindin D28k. Superimposed camera lucida drawings revealed close correspondence between MOR-rich regions and regions poor in calbindin and somatostatin fibers. However, this correspondence was evident only in the ventral 2/3 of the rostral caudate-putamen (CPu) and core of the nucleus accumbens (AcbC). In the dorsal CPu at rostral levels, the shell of the accumbens (AcbSh), the olfactory tubercle, and the entire CPu caudal to the posterior limb of the anterior commissure, there was no obvious relationship among these three markers. These results suggest that the entire striatum can be divided into a core and a shell. The core is found in the rostral-ventral region, where there is close correspondence among several patch-matrix markers. The surrounding shell consists of the AcbSh, olfactory tubercle, and an extensive region of the CPu dorsal and caudal to the core, where the patch-matrix markers do_ not coincide.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Heimer, L., D.S. Zahm and G.F. Alheid. Basal Ganglia. In Paxinos, G. The Rat Nervous System. 2nd Edition, 1995 Academic Press, San Diego.
Heimer, L., G. Alheid, J. de Olmos, H. Groenewegen, S. Haber, R.E. Harlan, and S. Zahm (1997) The Accumbens: Beyond the Core-Shell Dichotomy. J. Neuropsychiatry, 9: 354–381.
Heimer, L., R.E. Harlan, G.F. Alheid, M. Garcia and J. De Ohnos (1997) Substantia innominata: A notion which impedes clinical-anatomical correlations in neuropsychiatric disorders. Neuroscience, 76: 957–1006.
Graybiel, A.M. and C.W. Ragsdale (1978) Histochemically distinct compartments in the striatum of human, monkey, and cat demonstrated by acetylcholinesterase staining. Proc. Natl. Acad. Sci. USA 75: 5723–5726.
Graybiel, A.M., A.W. Flaherty and J.-M. Gimenez-Amaya (1990) Striosomes and matrisomes. In G. Bernardi (ed): The Basal Ganglia Ill. New York: Plenum Press, pp. 3–12.
Song, D.D. and R.E. Harlan (1994) Genesis and migration patterns of neurons forming the patch and matrix compartments of the rat striatum. Dev. Brain Res. 83: 233–146.
Flaherty, A.W. and A.M. Graybiel (1993) Output architecture of the primate putamen. J. Neurosci. 13: 3221–3237.
Flaherty, A.W. and A.M. Graybiel (1994) Input-output organization of the primate putamen. J. Neurosci. 14: 599–610.
Selemom. L.D. and P.S. Goldman-Rakic (1995) Topographical intermingling of striatonigral and striatopallidal neurons in the rhesus monkey. J. Comp. Neurol. 297: 359–376.
Gerfen, C.R. (1992) The neostriatal mosaic—Multiple levels of compartmental organization in the basal ganglia. Annu. Rev. Neurosci. 15: 285–320.
Harlan, R.E. and M.M. Garcia. (1995) Charting of Jun family member proteins in the rat forebrain and midbrain: lmmunocytochemical evidence for a new Jun-related antigen. Brain Res. 692: 1–22.
Holt, D.J., A.M. Graybiel and C.B. Saper (1997) Neurochemical architecture of the human striatum. J.Comp. Neurol. 384: 1–25.
Fotuhi, M., T.M. Dawson, A.H. Sharp, L.J. Martin, A.M. Graybiel and S.H. Snyder (1993) Phosphoinositide second messenger system is enriched in striosomes: Immunohistochemical demonstration of inositol 1,4,5-triphosphate receptors and phospholipase C ß and y in primate basal ganglia. J. Neurosci. 13: 3300–3308.
Martin, L. J., M.G. Hadfield, T.L. Dellovade, and D.L. Price (1991) The striatal mosaic in primates: Patterns of neuropeptide immunoreactivity differentiate the ventral striatum from the dorsal striatum. Neurosci. 43: 397–417.
Graybiel, A.M., C.W. Ragsdale, E.S. Yoneoka and R.P. Elde (1981) An immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat, with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase staining. Neuroscience 6: 377–397.
Jongen-Relo, A.L., H.J. Groenewegen and P. Voorn (1993) Evidence for a multi-compartmental histochemical organization of the nucleus accumbens in the rat. J. Comp. Neurol. 337: 267–276.
Francois, C., J. Yelnick, G. Percheron, and D. Tande (1994) Calbindin D-28k as a marker for the associative cortical territory of the striatum in macaque. Brain Res. 633: 331–336.
Gerfen, C.R., K.G. Baimbridge and J.J. Miller (1985) The neostriatal mosaic: compartmental distribution of calcium binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc. Natl. Acad. Sci. USA 82: 8780–8784.
Mengual, E., C. Casanovas-Aquilar, J. Perez-Clausel], and J.M. Gimenez-Amaya (1995) Heterogeneous and compartmental distribution of zinc in the striatum and globus pallidus of the rat. Neurosci. 66: 523–537.
Zahm, D.S. and J.S. Brog (1992) On the significance of subterritories in the accumbens part of the rat ventral striatum. Neurosci. 50: 751–767.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Harlan, R.E., Guillot, M., Garcia, M.M. (2002). Re-Evaluation of Markers for the Patch-Matrix Organization of the Rat Striatum. In: Graybiel, A.M., Delong, M.R., Kitai, S.T. (eds) The Basal Ganglia VI. Advances in Behavioral Biology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0179-4_40
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0179-4_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4955-6
Online ISBN: 978-1-4615-0179-4
eBook Packages: Springer Book Archive