Summary
Our in vitro data indicate that peripheral blood monocytes or monocyte-derived immature dendritic cells under appropriate culture conditions transdifferentiate into endothelial-like cells (ELC), which are characterized by the expression of endothelial markers and the formation of tube-like structures. Dependent on the culture conditions a mixed macrophage/endothelial or an endothelial phenotype could be induced. A similar pattern of development could be seen in CD14+ monocyte-derived ELC and ELC grown from CD34+ precursor cells or from dendritic cells generated from CD34+ cells. These in vitro data suggest that monocytes are precursors of different subgroups of endothelial cells and that the formation of endothelial cells from CD34+ progenitor cells follows a similar pathway possibly via the monocyte and/or the immature dendritic cell.
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Havemann, K., Pujol, B.F., Adamkiewicz, J. (2003). In Vitro Transformation of Monocytes and Dendritic Cells into Endothelial like Cells. In: Moldovan, N.I. (eds) Novel Angiogenic Mechanisms. Advances in Experimental Medicine and Biology, vol 522. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0169-5_6
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DOI: https://doi.org/10.1007/978-1-4615-0169-5_6
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