Abstract
Retinal neovascular diseases such as diabetic retinopathy and retinopathy of prematurity are among the leading causes of vision impairment throughout the world. Retinal neovascularization is thought to occur in response to a hypoxic insult, which leads to changes in the existing microvasculature such as pericyte death and subsequent endothelial cell proliferation.1.2 Compensatory neovascularization then results in the formation of aberrant and pathologic capillaries. An important question whose answer would have broad implications for potential therapeutic strategies is the origin of the cells responsible for compensatory neovascularization.
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Keywords
- Hematopoietic Stem Cell
- Proliferative Diabetic Retinopathy
- Vascular Endothelial Growth Factor Gene
- Chimeric Mouse
- Retinal Neovascularization
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Grant, M.B. et al. (2003). The Contribution of Adult Hematopoietic Stem Cells to Retinal Neovascularization. In: Moldovan, N.I. (eds) Novel Angiogenic Mechanisms. Advances in Experimental Medicine and Biology, vol 522. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0169-5_5
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DOI: https://doi.org/10.1007/978-1-4615-0169-5_5
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