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Role of the Plasminogen and MMP Systems in Wound Healing

  • Chapter
Plasminogen: Structure, Activation, and Regulation

Abstract

Wound healing involves cell migration and tissue remodeling, which require degradation of extracellular matrix (ECM). Two proteolytic systems, the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems can degrade most ECM components. Plasmin can only degrade some components of the ECM directly, such as laminin and flbronectin, whereas other components such as elastin and collagen are degraded by MMPs. The plasminogen/plasmin system can, however, play a role in the activation of several proMMPs. Thus, in concert, both systems can degrade the ECM. In this chapter we will review the contribution of both proteolytic systems to neointima formation and arterial restenosis after vascular injury, allograft transplant stenosis, skin wound healing, and myocardial ischemia.

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  1. Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O & N, Herestraat 49, B-3000, Leuven, Belgium

    H. Roger Lijnen & Désiré Collen

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  1. H. Roger Lijnen
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  1. Department of Biochemistry & Molecular Biology and Oncology, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada

    David M. Waisman

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Lijnen, H.R., Collen, D. (2003). Role of the Plasminogen and MMP Systems in Wound Healing. In: Waisman, D.M. (eds) Plasminogen: Structure, Activation, and Regulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0165-7_11

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  • DOI: https://doi.org/10.1007/978-1-4615-0165-7_11

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