Leptin and Pubertal Development in Humans

  • Susann Blüher
  • Christos S. Mantzoros


Since the discovery of leptin through positional cloning of the ob gene (Zhang et al., 1994) more than 8 years ago, extensive research efforts have focused on the biology and physiology of this hormone. Leptin is a 167-amino acid protein that is structurally related to members of the long-chain helical cytokine family (Madej et al., 1995; Zhang et al., 1997). It is expressed primarily in white adipose tissue (Maffei et al., 1995; Klein et al., 1996; Leroy et al., 1996). Leptin expression has also been detected in the stomach (Bado et al., 1998), hypothalamus (Morash et al., 1999), pituitary (Jin et al., 2000), skeletal muscle (Wang et al., 1998) placenta (Masuzaki et al., 1997), mammary gland (Smith-Kirwin et al., 1998; Aoki et al., 1999), and possibly in brown fat.


Luteinizing Hormone Anorexia Nervosa Bulimia Nervosa Pubertal Development Tanner Stage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Susann Blüher
    • 1
  • Christos S. Mantzoros
    • 1
  1. 1.Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical CenterHarvard Medical SchoolUSA

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