Strategies Leading To MT2 Selective Melatonin Receptor Antagonists

  • Gilberto Spadoni
  • Annalida Bedini
  • Giovanni Piersanti
  • Marco Mor
  • Silvia Rivara
  • Giorgio Tarzia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 527)


Studies of the physiological actions of melatonin have been hindered by the lack of specific, potent and subtype selective agonists and antagonists. This paper reviews our progress in developing subtype selective melatonin antagonists. Evidence is presented suggesting the structural features conferring MT2 selective antagonism.


NIH3T3 Cell Intrinsic Activity Indole Derivative Melatonin Receptor Subtype Selectivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Gilberto Spadoni
    • 1
  • Annalida Bedini
    • 1
  • Giovanni Piersanti
    • 1
  • Marco Mor
    • 2
  • Silvia Rivara
    • 2
  • Giorgio Tarzia
    • 1
  1. 1.Istituto di Chimica Farmaceutica e TossicologicaUniversità degli Studi di UrbinoUrbinoItaly
  2. 2.Dipartimento FarmaceuticoUniversità degli Studi di ParmaParmaItaly

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