Abstract
A fundamental question in animal nutrition is the amino acid requirement induced by inflammation and immune response. The aim of the present experiment was to study the effect of chronic lung inflammation induced by injection of complete Freund adjuvant on amino acid metabolism in pigs. For 10 days, we compared plasma haptoglobine and amino acid concentrations of piglets with chronic lung inflammation (CFA) with those of pair-fed littermate healthy pigs (CONTROL). Tryptophan was the only amino acid for which the plasma concentration was continously decreasing and did not reach the control level at the end of the experimental period. We suggested that an increase in tryptophan catabolism under indoleamine 2, 3 dioxygenase activation and lor tryptophan incorporation into acute phase protein could explained the decrease in plasma tryptophan concentration in pigs suffuring from chronic lung inflammation.
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References
. P.H. Sugarbaker, N.R. Dummick, E.V. Sigarbaker, Diagnosis and staging, in: Cancer, principles and practice of oncology, edited by VT De Vita, S. Hellman, SA Rosenberg (JB LippinCOit, Philadelphia. 1982 ), pp. 223 – 230.
. J.A. Norton, M. Maher, R. Wesley. D. White. M.F. Brennan, Glucose intolerance in sarcoma patients. Cancer 54, 3022 – 3027 (1984).
. P.S. Schein, D.D. Kisner, D. Haller, M. Blecher, M. Hamosh, Cachexia of malignancy. Potential role of insulin in nutritional management, Cancer 43, 2070 – 2076 (1979).
. K. Lundholm, A.C. Bylund, T. Schersten, Glucose tolerance in relation to skeletal muscle enzyme activities in cancer patients, Scam!. J. Clin. Lab. Invest. 37. 267 – 272 (1977).
. R.G. Douglas. J.H.F. Shaw. Metabolic elTect of cancer, Br. J. Surg. 77. 246 – 254 (1990).
. R.T. Chlebowski. L. Bulcavage, M. Grosvenor, et aI., Hydrazine sulfate in cancer patients with weight loss. A placeb-controlled clinical experience, Cancer 59, 406 – 410 (1987).
. C. Waterhouse, Lactate metabolism in patients with cancer, Cancer 33, 66 – 71 (1974).
. C. Waterhouse. N. Jeanpetre. J. Keilson, Gluconeogenesis from alanine in patients with progressive malignant disease. Cancer Res. 39, 1968 – 1972 (1979).
. A. Cascino, C. Cangiano, F. Ceci, et aI., Plasma amino acid in human cancer: individual role of tumor, malnutrition and glucose toerance, Clin. Nutr. 7, 213 – 216 (1988).
. M. Muscaritoli, C. Cangiano, A. Cascino, F. Ceci, L. Giacomelli, P. Cardelli Cangiano, M. Mulieri, F. Rossi Fanelli, Plasma clearance of exogenous lipids in patients with malignant disease. NlIIritiol1 6, 147 – 151 (1990).
11. .I.A. Norton. T.P. Stein. M.F. Brennan . Whole body protein synthesis and turnover in normal man and malnourished patients with and without known cancer, Ann. Surg. 194, 123–128 (1981 ).
. R.S. Wan·en. M..Ieevanandam. M.F. Bennan, Protein synthesis in the tumor-intluen~ed hepatocyte, Surge/)" 98. 275 – 282 (1985).
. K. Lundholm, K. Bennegard. E. Eden, G. Svaninger. P.W. Emery. MJ. Rennie, Efflux of 3-methylhistidine from the leg in cancer patients who experience weight loss, Cancer Res. 42. 4807 – 4811 (1982).
. A. Cascino, M. Muscaritoli, C. Cangiano, L. Conversano, A. Laviano, S. Ariemma, M.M. Meguid, F. Rossi Fanelli, Plasma amino acid imbalance in patients with lung and breast cancer, Anticancer Res. IS, 507 – 510 (1995).
. F. Rossi Fanelli, C. Cangiano. F. Ceci. R. Cellerino. F. Franchi, E.T. Menichetti, M. Muscaritoli. A. Cascino, Plasma tryptophan and anorexia in human cancer. Eur. J. Cancer Clin. Onco/. 22. 89 – 95 (1986).
. C. Cangiano. A. Cascino. F. Ceci. et aI., Plasma and CSF tryptophan in cancer anorexia. J. Neural Transm. 81, 225 (1990).
. A. Cascino, C. Cangiano, F. Ceci, F. Franchi, T. Mineo, M. Mulieri, M. Muscaritoli, F. Rossi Fanelli, Increased plasma free tryptophan levels in human cancer: a tumor related effect? Anticancer Res. II. 1313 – 1316 (1991).
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Melchior, D., Le Melchior, N., Sève, B. (2003). Effects of Chronic Lung Inflammation on Tryptophan Metabolism in Piglets. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_40
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DOI: https://doi.org/10.1007/978-1-4615-0135-0_40
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