Role Of Brain Tryptophan And Serotonin In Secondary Anorexia

  • Filippo Rossi-Fanelli
  • Alessandro Laviano
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 527)


Anorexia and reduced energy intake contribute to worsen the prognosis of’ patients suffering from a number of chronic diseases, by promoting skeletal muscle wasting, leading to the development of malnutrition and eventually cachexia. The pathogenesis of cancer anorexia is still matter of debate. Many possible mediators, including hormones, peptides, and neurotransmitters, appear to be involved. However, consistent animal and clinical data suggest that brain tryptophan and serotonin may represent a common final pathway shared by many contributing factors. Supporting this hypothesis, recent data showed that the manipulation of brain tryptophan availability ameliorates anorexia and food intake in cancer patients


Energy Intake POMC Neuron Tryptophan Level Reduce Energy Intake Brain Tryptophan 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Filippo Rossi-Fanelli
    • 1
  • Alessandro Laviano
    • 1
  1. 1.Department of Clinical MedicineUniversity “La Sapienza”RomeITALY

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