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Fibroblast Growth Factors and Neuroprotection

  • Chapter
Molecular and Cellular Biology of Neuroprotection in the CNS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 513))

Abstract

The FGFs comprise a large group of structurally similar polypeptide mitogens which currently includes 22 different members. The first members of this family, FGF1 (acidic FGF, aFGF) and FGF2 (basic FGF, bFGF), were described in 1986 by Jaye et all and Abraham et al.2 In the meantime, 20 other FGFs have been discovered which were designated FGF3 FGF23. FGF19 has so far only been described in humans and FGF 15 only in mice, and it has been suggested that FGF 19 is the human ortholog of mouse FGF 15. All members of the FGF family range in molecular weight from 17 to 34 kDa in vertebrates, and some of them are glycosylated (for review see ref. 3).

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Authors and Affiliations

  1. Institute of Physiology, University of Munich, Pettenkoferstr. 12, D-80336, Munich, Germany

    Christian Alzheimer

  2. Institute of Physiology, University ofKiel, 24098, Kiel, Germany

    Christian Alzheimer

  3. Institute of Cell Biology, ETH-Z rich, Hnggerber g, CH-8093, Zurich, Switzerland

    Sabine Werner

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  1. Christian Alzheimer
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  2. Sabine Werner
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  1. Institute of Physiology, University of Kiel, Kiel, Germany

    Christian Alzheimer

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© 2003 Springer Science+Business Media New York

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Alzheimer, C., Werner, S. (2003). Fibroblast Growth Factors and Neuroprotection. In: Alzheimer, C. (eds) Molecular and Cellular Biology of Neuroprotection in the CNS. Advances in Experimental Medicine and Biology, vol 513. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0123-7_12

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  • DOI: https://doi.org/10.1007/978-1-4615-0123-7_12

  • Publisher Name: Springer, Boston, MA

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