Taurine 5 pp 67-73 | Cite as

Taurine Reduces Mortality in Diabetic Rats

Taurine and Experimental Diabetes Mellitus
  • Flavia Franconi
  • Stefano A. Santini
  • Nicolò Gentiloni Silveri
  • Salvatore Caputo
  • Bruno Giardina
  • Giovanni Ghirlanda Silveri
  • Mauro A. S. Di Leo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 526)


Diabetes mellitus affects more that 6% of the US population and its prevalence is increased by 30% in the last decade, dramatically in younger individuals. In fact, it kills more people annually than AIDS and breast cancer combined and when the long-term complications and their costs are considered, the implications of these numbers are sobering1. Although, good glycemic control can delay the development and progression of microvascular complications (retinopathy, nephropathy), such metabolic control is often difficult to achieve and to maintain and it is not yet clear whether the same is true for macrovascular complications, such as coronary heart disease, stroke2. In this regard, it is important to note that clinical studies show that diabetic patients treated with phenformin and tolbutamide3have lower blood glucose levels, but also an increased overall mortality and cardiovascular mortality. Thus, diabetic therapy should lead to a lower incidence of diabetic complications and, ultimately to lower mortality. The logical corollary to this question is which of the new treatment options will affect long-term diabetic mortality. In this contest, the correction of oxidative stress may have important implications in preventing diabetes-induced alterations, since one of the consequences of chronic hyperglycemia is enhanced oxidative stress3and reactive oxygen species have been implicated in the pathogenesis of many diabetic complications4.


Hypoglycemic Effect Good Glycemic Control Heart Protection Study Lower Blood Glucose Level Taurine Supplementation 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Flavia Franconi
    • 1
  • Stefano A. Santini
    • 2
  • Nicolò Gentiloni Silveri
    • 3
  • Salvatore Caputo
    • 4
  • Bruno Giardina
    • 2
  • Giovanni Ghirlanda Silveri
    • 4
  • Mauro A. S. Di Leo
    • 3
  1. 1.Department of Pharmacology and Center for Biotechnology Development and Biodiversity ResearchUniversity of SassariItaly
  2. 2.Institute of Biochemistry and Clinical BiochemistryCatholic UniversityRomaItaly
  3. 3.Departments of Emergency MedicineCatholic UniversityRomaItaly
  4. 4.Department of Internal and Geriatric MedicineCatholic UniversityRomaItaly

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