Taurine has been shown to protect against lung injury induced by various oxidants such as ozone, nitrogen dioxide, amiodarone and paraquat and in combination with niacin to protect against bleomycin induced lung injury1–6The protective effects of taurine may be explained by its detoxification of hypochlorous acid, a potent oxidant which can cause extensive tissue damage7. However, recent evidence from our laboratories8–10and others11,12demonstrate that taurine chloramine (Tau-Cl), produced from highly toxic hypochlorous acid and taurine, is thought to be pivotal in regulating inflammation. Our previous in vitro data demonstrate that Tau-Cl inhibits proinflammatory mediators such as NO and TNF-α secreted from lipopolysaccharide (LPS) and gamma interferon activated murine macrophages8,9.
- Nitric Oxide
- Lung Inflammation
- Hypochlorous Acid
- Supplemental Taurine
- Lung Damage
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Schuller-Levis, G.B., Gordon, R.E., Wang, C., Park, E. (2003). Taurine Reduces Lung Inflammation and Fibrosis Caused By Bleomycin. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_48
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