Abstract
Taurine has been shown to protect against lung injury induced by various oxidants such as ozone, nitrogen dioxide, amiodarone and paraquat and in combination with niacin to protect against bleomycin induced lung injury1–6The protective effects of taurine may be explained by its detoxification of hypochlorous acid, a potent oxidant which can cause extensive tissue damage7. However, recent evidence from our laboratories8–10and others11,12demonstrate that taurine chloramine (Tau-Cl), produced from highly toxic hypochlorous acid and taurine, is thought to be pivotal in regulating inflammation. Our previous in vitro data demonstrate that Tau-Cl inhibits proinflammatory mediators such as NO and TNF-α secreted from lipopolysaccharide (LPS) and gamma interferon activated murine macrophages8,9.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wang, Q., Giri, S.N., Hyde, D.M. and Li, C., 1991, Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. Biochem Pharmacol. 42:1115–1122.
Wang, Q., Giri, S.N., Hyde, D.M. and Nakashima, J.M., 1989, Effects of taurine on bleomycin induced lung fibrosis in hamsters. Proc. Soc. Exp. Biol. Med. 190: 330–338.
Gordon, R.E. and Heller, R.F., 1992, Taurine protection of lungs in hamster models of oxidant injury; a morphological time study of paraquat and bleomycin treatment. In Taurine, edited by J. B. Lombardini, Plenum Press, New York. 319–328.
Schuller-Levis, G.B., Gordon, R.E., Park, E., Pendino, K.J. and Laskin, D.L., 1995, Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia. Exp.Lung Res. 21:877–888.
Wang, Q.J., Hollinger, M.A., Giri, S.N., 1992, Attenuation of amiodarone-induced lung fibrosis and phopholipidosis in hamsters by taurine and/or niacin treatment. J. Pharmacol. Exp. Ther. 262:127–132.
Gould, R.E., Shaked, A.A., Solano, D.F., 1986, Taurine protects hamster bronchiols from acute NO2. induced alteration. Am. J. Pathol. 125:585–600.
Lambert, M.B. and Weiss, S.J., 1983, The chlorinating potential of the human monocyte. Blood, 62: 645–651.
Park, E., Quinn, M. R., Wright C. and Schuller-Levis, G.B., 1993, Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor alpha in RAW 264.7 cells. J. Leukoc. Biol. 54: 119–124.
Park, E., Schuller-Levis, G.B. and Quinn, M. R., 1995, Taurine chloramine inhibits production of nitric oxide and TNF-a in activated RAW 264.7 cells by mechanisms that induce transcriptional and translational events. J. Immunol 154:4778–4784.
Kim, C., Park,. E., Quinn M.R. and Schuller-Levis G.B., 1996, The production of superoxide anion and nitric oxide by cultured murine leukocytes and the accumulation of TNF-a in conditioned media is inhibited by taurine chloramine. Immunopharmacol. 34:89–95.
Marcinkiewicz, J., Grabowska, A., Bereta, J., Stelmaszynska, T., 1995, Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators. J. Leukoc. Biol. 58:667–674.
Kontny, E., Grabowska, A., Kowalczewski, J., Kurowska, M., Janicka, I., Marcinkiewicz, J., Maslinskki, W., 1999, Taurine chloramine inhibition of cell proliferation and cytokine production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheum. 42:2552–2560.
Adamson, I.Y., and Bowden, D.H., 1974, The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 77:185–197.
Marin, M.L., Hardy, M.A., Gordon, R.E., Reemtsma, K., and Benvenisty, A.I., 1990, Immunomodulation of vascular endothelium III effects of UVB irradiation on vein allograft rejection. J. Vasc. Surg. 11:103–111
Green, T.R., Fellman, J.H., Eicher, A.L. and Pratt, K.L., 1991, Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim. Biophys Acta. 1073: 91–97.
Fukuda, K., Hirai, Y., Yoshida, H., Hakajima, T., Usii, T., 1982, Free amino acid content of lymphocytes and granulocytes compared. Clin. Chem. 28, 1758–1761.
Vanhee, D., Delneste, Y., Lassalle, P., Gosset, P., Joseph, M., Tonnel, A.B., 1994, Modulations of endothial cell adhesion molecule expression in a situation of chronic inflammatory stimulation. Cell Immumol 155;2:446–456.
Huot, A. and Hacker, M., 1990, Role of reactive nitrogen intermediate production in alveolar macrophage mediated cytostatic activity induced by bleomycin lung damage in rats. Cancer Res. 50:7863–7866.
Gurujeylakshimi, G., Wang, Y. and Giri, S.N., 2000, Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. Nitric Oxide. 4:399–411.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Schuller-Levis, G.B., Gordon, R.E., Wang, C., Park, E. (2003). Taurine Reduces Lung Inflammation and Fibrosis Caused By Bleomycin. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_48
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0077-3_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4913-6
Online ISBN: 978-1-4615-0077-3
eBook Packages: Springer Book Archive