Taurine 5 pp 261-267 | Cite as

Effect of Taurine on Cholesterol Degradation and Bile Acid Pool in Rats Fed a High-Cholesterol Diet

  • Wen Chen
  • Naomichi Nishimura
  • Hiroaki Oda
  • Hidehiko Yokogoshi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 526)


Taurine, one of the most abundant free amino acids in many animals tissues, is well known to have several beneficial physiological actions, including antioxidation, detoxification, osmoregulation, cell membrane stabilization, and neuromodulation, etc1–5. In lipid metabolism, the function of taurine is considered primarily to be the conjugation with bile acids in the liver6. Bile acid is the degrading metabolite of cholesterol, and is secreted into the small intestine to promote lipid absorption. Therefore, 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acid, becomes a major point in many studies on the effects of taurine on lipid metabolism.


Bile Acid High Cholesterol Diet VLDL Fraction Abundant Free Amino Acid Fecal Cholesterol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Wright, C.E., Tallan, H.H., Lin, Y.Y., 1986, Taurine: biological update.Annu. Rev Biochem.55:427–453.PubMedCrossRefGoogle Scholar
  2. 2.
    Huxtable,R.J., 1992, Physiological actions of taurine.Physiol. Rev.72:101–163.PubMedGoogle Scholar
  3. 3.
    Kuriyama, K., 1980, Taurine as a neuromodulator.Federation Proceeding.39:2680–2684.Google Scholar
  4. 4.
    Thurston, J.H., Hauhart, R.E., Dirgo, J.A., 1980, Taurine: A role in osmotic regulation of mammalian brain and possible clinical significances.Life Sci26:1561–1568.PubMedCrossRefGoogle Scholar
  5. 5.
    Pasantes Morales,.H., Wright, C.E., Gaull, G.E., 1985, Taurine protection of lymphoblastoid cells from iron-ascorbate-induced damage.Biochem. Pharmacol.34:2205–2207.CrossRefGoogle Scholar
  6. 6.
    Danielsson, H., 1963, Present states of research on catabolism and excretion of cholesterol.Adv. Lipid Res.1:335–385.PubMedGoogle Scholar
  7. 7.
    Sugiyama, K., Ohishi, A., Ohnuma, Y., Muramatsu, K., 1989, Comparison between the plasma cholesterol-lowering effects of glycine and taurine in rats fed on high cholesterol diet.Agric Biol Chem.53: 1647–1652.CrossRefGoogle Scholar
  8. 8.
    Yan, C.C., Bravo, E., Cantafora, A., 1993, Effect of taurine levels on liver lipid metabolism: an in vivo study in the rat.Proc Soc Exp Biol Med.202: 88–96.PubMedGoogle Scholar
  9. 9.
    Nanami, K., Oda, H., Yokogoshi, H., 1996, Antihypercholesterolemic action of taurine on streptozotocin-diabetic rats or on rats fed a high cholesterol diet.Taurine 2 edited by Huxtable et al. Plenum Press New Yorkpp.561–568.Google Scholar
  10. 10.
    .Mochizuki, H., Oda, H., Yokogoshi, H., 1998, Amplified effect of taurine on PCB-induced hypercholesterolemia in rats. Taurine3: 285-290, Plenum Press, New York. Google Scholar
  11. 11.
    Folch, J., Lees, M., Sloane-Stanley, G.H., 1957, A simple method for the isolation and purification of total lipids from animal tissuesJ. Biol. Chem.226:497–509.PubMedGoogle Scholar
  12. 12.
    Sheltawy, M.J., Losowsky, M.S., 1975, Determination of fecal bile acid by an enzymatic method.Clin. Chim. Acta.64:127–132.PubMedCrossRefGoogle Scholar
  13. 13.
    Ogishima, T., Okuda, K., 1986, An improved method for cholesterol 7q.-hydroxylase activityAnalytical Biochemistry158:228–232.PubMedCrossRefGoogle Scholar
  14. 14.
    Sugiyama, K., Ohishi, A., Ohnuma, Y., Muramatsu, K., 1989, Comparison between the plasma cholesterol-lowering effects of glycine and taurine in fats fed on high cholesterol dietsAgri. Biol. Chem.53:1647–1652.CrossRefGoogle Scholar
  15. 15.
    Shneider, B L., 2001, Intestinal bile acid transport: biology, physiology, and pathophysiologyJ Pediatr Gastroenterol Nutr.32(4):407–41.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Wen Chen
    • 1
  • Naomichi Nishimura
    • 2
  • Hiroaki Oda
    • 3
  • Hidehiko Yokogoshi
    • 1
  1. 1.School of Food and Nutritional SciencesThe University of ShizuokaShizuokaJapan
  2. 2.Department of Human Life and DevelopmentNayoro City CollegeNayoroJapan
  3. 3.Department of Applied Biological SciencesNagoya UniversityNagoyaJapan

Personalised recommendations