Effect of Taurine on Cholesterol Degradation and Bile Acid Pool in Rats Fed a High-Cholesterol Diet
Taurine, one of the most abundant free amino acids in many animals tissues, is well known to have several beneficial physiological actions, including antioxidation, detoxification, osmoregulation, cell membrane stabilization, and neuromodulation, etc1–5. In lipid metabolism, the function of taurine is considered primarily to be the conjugation with bile acids in the liver6. Bile acid is the degrading metabolite of cholesterol, and is secreted into the small intestine to promote lipid absorption. Therefore, 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acid, becomes a major point in many studies on the effects of taurine on lipid metabolism.
KeywordsBile Acid High Cholesterol Diet VLDL Fraction Abundant Free Amino Acid Fecal Cholesterol
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