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Taurine 5 pp 17-23 | Cite as

Taurine on Sino-Atrial Nodal Cells

Ca2+-Dependent Modulation
  • Hiroyasu Satoh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 526)

Abstract

Taurine, 2-aminoethanesulfonic acid, is a sulfur amino acid that is widely distributed in the body and is involved in many physiological processes1,2. Although taurine is classified as an α-amino acid, it is not incorporated into proteins or membranes. Taurine is present in high concentration (around 10 mM) within myocardial cells, but is found in relatively low levels in the plasma3. It has been found to exert many electrical and mechanical actions on cardiac muscle cells4–7including a positive inotropic effect8,9 and protective action against cellular calcium overload and cardiomyopathy10. Thus, there are many electropharmacological effects of taurine on cardiac muscle cells, but the underlying mechanisms still remain unclear. In the sino-atrial (SA) node, taurine might be a potent modulator of spontaneous activity. The actions of taurine on cardiac pacemaker currents of the SA node are discussed here.

Keywords

Action Potential Duration Sinoatrial Node Negative Chronotropic Effect Positive Chronotropic Effect Spontaneous Beating 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Hiroyasu Satoh
    • 1
  1. 1.Department of Pharmacology, Division of Molecular and Cellular BiologyNara Medical UniversityKashihara, NaraJapan

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