Abstract
Taurine and sulfate are major end products of L-cysteine metabolism in mammals1, and they play various roles as tissue constituents and physiologically important compounds. Taurine is found in high concentrations in skeletal and heart muscle and brain2. It is utilized for the synthesis of taurine conjugates of bile acids. It is believed that most taurine is produced via the cysteinesulfinate pathway3and cysteamine pathway4. In both pathways, hypotaurine is an obligatory precursor leading to taurine. Hypotaurine content in animal tissues is far less than the taurine content. However, it has been reported that hypotaurine is found in rat brain5, accumulates in the liver of cysteine-administered rats3and in the regenerating rat liver6, increases in blood of rats injected with L-cysteine7, and is excreted in the urine of rats fed L-cystine8. When hypotaurine was injected into rats, urinary taurine excretion increased in a dose-dependent manner9.
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References
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Nakamura, H., Ubuka, T. (2003). Determination of Taurine and Hypotaurine in Animal Tissues by Reversed-Phase High-Performance Liquid Chromatography after Derivatization with Dabsyl Chloride. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_28
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DOI: https://doi.org/10.1007/978-1-4615-0077-3_28
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