Taurine 5 pp 183-187 | Cite as

Isovolumetric Regulation in Mammal Cells: Role of Taurine

  • B. Ordaz
  • R. Franco
  • K. Tuz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 526)


The ability to regulate cell volume is an ancient conserved trait present in essentially all species through evolution. The maintenance of a constant cell volume is a homeostatic imperative in animal cells. Changes in cell water content affecting the concentration of intracellular messenger molecules impair the complex signaling network, crucial for cell functioning and intercellular communication. Although the renal homeostatic mechanisms exert a precise control of extracellular fluid osmolarity, this is challenged in a variety of pathological situations. The intracellular volume constancy is continuously compromised by the generation of local and transient osmotic microgradients, associated with nutrients uptake, secretion, cytoskeleton remodeling and transynaptic ionic gradients1.


Hippocampal Slice Regulatory Volume Decrease Osmotic Gradient Niflumic Acid Regulate Cell Volume 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • B. Ordaz
    • 1
  • R. Franco
    • 1
  • K. Tuz
    • 1
  1. 1.Department of Biophysics, Institute of Cell PhysiologyNational University of MexicoMexico CityMexico

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