A Modeling Investigation to the Possible Role of Myoglobin in Human Muscle in Near Infrared Spectroscopy (NIRS) Measurements

  • Louis Hoofd
  • Willy Colier
  • Berend Oeseburg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 530)

Abstract

Near Infrared Spectroscopy (NIRS) analyzes infrared light having traveled through tissue, for its oxygenation status. The main chromophore analyzed is hemoglobin (Hb), but in muscle tissue also myoglobin (Mb) is present. Since NIRS cannot discern between these two species experimentally, we did model calculation studies using general data for human muscle. Where such data were not directly available, we derived these from analogous data or straightforward assumptions. Consequently, conclusions have to be drawn cautiously. Solid conclusions are, that myoglobin is an important factor with red muscle, and that it is always partly desaturated, significantly depending on workload. Here, both deoxygenated Hb and Mb as detected by NIRS varied between 0.04 and 0.13 mol/m3, while the variation in Mb saturation (53–86%) even exceeded that of Hb (63–84%).

Key words

muscle myoglobin near infrared spectroscopy tissue oxygenation 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Louis Hoofd
    • 1
  • Willy Colier
    • 1
  • Berend Oeseburg
    • 1
  1. 1.237 Department of PhysiologyUniversity of NijmegenNijmegenThe Netherlands

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