Arterial Pulsations are Present in One Third of the Human Cranial Vascular Volume Penetrated by Near Infrared Light

  • Robert Stingele
  • Emanuela Keller
  • Benedicht P. Wagner
  • Thorsten Steiner
  • Karoline Stingele
  • Werner Hacke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 530)

Abstract

The percentage of cranial vascular volume that undergoes arterial pulsations is estimated by 18 paired measurements in nine healthy volunteers using near infrared spectroscopy (NIRS, 10 Hz sampling frequency, 769 nm). The NIR absorption is decomposed in pulsatile and non-pulsatile components by digital filtering. The time course of absorption changes of these components after sudden intravenous injection of indocyanine-green (ICG) is used to estimate the arterial fraction of vascular volume (f art ). Approximately 28% of the vascular volume within the optical field of the NIR spectroscope was arterial. The range of values was 6 – 43%. Variance of f art was 4.8 times higher between subjects than within subjects, indicating that the variability observed is not due to imprecise estimation but to optode position and subject.

Key words

Blood volume humans indocyanine-green NIRS 

Abbreviations

Atot,Aart,Aven,Ap

NIR absorptions originating in volumes with corresponding indices

Ap

instantaneous power of pulsatile absorption

Anp
non-pulsatile absorption originating inA ven and
$$ \bar{V} $$
art
fart

arterial fraction of arterial vascular volume

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References

  1. 1.
    Oppenheim AV and Schafer RW. Discrete-Time Signal Processing. In: Prentice Hall Signal Processing Series 1st ed. Englewood Cliffs: Prentice Hall, 1989.Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Robert Stingele
    • 1
  • Emanuela Keller
    • 2
  • Benedicht P. Wagner
    • 3
  • Thorsten Steiner
    • 1
  • Karoline Stingele
    • 1
  • Werner Hacke
    • 1
  1. 1.Department of NeurologyUniversity of HeidelbergGermany
  2. 2.Department of NeurosurgeryUniversity of ZürichSwitzerland
  3. 3.Department of PediatricsUniversity of BerneSwitzerland

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