Abstract
The ability to differentiate between well-oxygenated and poorly-oxygenated tumors may play an important role in selecting an optimal therapeutic regime for tumor treatment of the individual patient. We present preliminary results in the development of a dynamic functional MRI method for mapping tissue oxygenation and blood flow distribution in humans simultaneously. We applied interleaved Blood Oxygenation Level Dependent (BOLD) and Flow-sensitive Alternating Inversion Recovery (FAIR) sequences to detect signals as a subject is inspiring gases of varying oxygen concentration. The method allows quantitation of the spatial distribution and time course of the important physiological functions that are easily registered with high resolution anatomic MR images. It may be used to critically evaluate the efficacy of varying durations of carbogen breathing in tumor patients, and allow a quantitative evaluation of the roles of carbogen and other radiosensitizers as potential adjuncts to radiotherapy and drug therapies.
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References
Ogawa S, Lee TM, Kay AR, Tank DW. “Brain magnetic resonance imaging with contrast dependent blood level oxygenation. Proc Natl Acad Sci (USA), 1990;87:9868–9872.
van Zijl PCM, Eleef SM, Ulatowski JA, Oja JME, Ulug AM, Traystman RJ & Kauppinen RA. Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nature Medicine, 1998;2:159–157.
Dennie J. Mandeville JB. Boxerman JL. Packard SD. Rosen BR. Weisskoff RM. NMR imaging of changes in vascular morphology due to tumor angiogenesis. Magn Reson Med 1998;40:793–799.
Davis TL, Kwog KK, Bandettini PA, Weisskoff RM, & Rosen BR. Mapping the dynamics of oxidative metabolism by functional MRI. ISMRM, 1997;151.
Kim S-G, Tsekos NV. Perfusion imaging by a flow-sensitive alternating inversion recovery (Fair) techniques: application to functional brain imaging. Magn Reson Med 1997;37:425–435.
Robinson SP, Howe FA, Rodrigues LM, Stbbs M, & Griffiths, JR. Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow. Seminars in Radiat Onc 1998;8:197–207.
Lin W. Paczynski RP. Celik A. Hsu CY. Powers WJ. Effects of acute normovolemic hemodilution on T2*-weighted images of rat brain. Magn Reson Med 1998; 40:857–864.
Zhong J, Fulbright RK, Kennan RP, & Gore JC. Quantification of intra-and extravascular contributions to BOLD effects induced by alteration in oxygenation or intravascular contrast agents. Magn Reson Med 1998; 40:526–536.
Prasad PV, Chen Q, Edelman RR, Epstein FH. Non-invasive evaluation of intra-renal oxygenation using BOLD MRI. Circulation 1996; 94:3271–3275.
Powell, M.E.B, S.A. Hill, M.I. Saunders, P.J. Hoskin, and D.J. Chaplin, Effect of carbogen breathing on tumor microregional blood flow in humans. Radiotherapy and Oncology, 1996;41,225–231.
Yang, Y., J.A. Frank, L. Hou, F.Q. Ye, A.C. McLaughlin, and J.H. Duyn, Multislice imaging of qunatitative cerebral perfusion with pulsed arterial spin labeling. Magn Reson Med. 1998; 39:825–832.
Thews O, Kelleher DK, and Vaupel P, Tumor oxygenation under normobaric and hyperbaric hyperoxia. Adv Expt Med Biology 1997;428,79.
Rubin, Hanley PJ, Keys HM, Marcial V, & Brady NL, Carbogen breathing during radiation therapy. Int J Radiol Oncol Biol Phys 1979;5,1963–1970.
Thews O, Kellleher DK, & Vaupel P. Tumor oxygenation under normobaric and hyperbaric hyperoxia. Oxygen Transport to Tissue XIX, ed. Harrison and Delpy, Plenum Press, New York, 1997.
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Zhong, J., Kwok, W.C.E., Okunieff, P. (2003). FMRI for Monitoring Dynamic Changes in Tissue Oxygenation/Blood Flow: Potential Applications for Tumor Response to Carbogen Treatment. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_42
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DOI: https://doi.org/10.1007/978-1-4615-0075-9_42
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