Abstract
Tumor oxygenation determines the efficacy of radiotherapy, but there is no non-invasive way to image this parameter. Since gradient recalled echo (GRE) images are sensitive to blood deoxyhæmoglobin concentration ([dHb]) they could have a role in assessing tumor oxygenation. In brain, linear relationships have been demonstrated between brain tissue R 2 * relaxation rate and tissue [dHb] or oxygen saturation, but in tumors, vascular and tissue heterogeneity, and the presence of simultaneous oxidative and glycolytic metabolism, complicate the analysis. We have studied the effects of vascular challenge in a rat prolactinoma tumor model by MR imaging and spectroscopy and comment on the implications of these results for calibrating GRE images for blood or tissue pO2.
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© 2003 Springer Science+Business Media New York
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Howe, F.A., Robinson, S.P., Rodrigues, L.M., Stubbs, M., Griffiths, J.R. (2003). Issues in GRE & Se Magnetic Resonance Imaging to Probe Tumor Oxygenation. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_41
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DOI: https://doi.org/10.1007/978-1-4615-0075-9_41
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