The Concept of Hemoglobin Equivalency of Perfluorochemical Emulsions
Perfluorochemical (PFC) emulsions have been in development as intravenous oxygen carriers for a number of years and many publications have dealt with their oxygen transport characteristics in both experimental models and in clinical trials. Though it has been stressed on numerous occasions that PFCs deliver oxygen to the tissues in very different ways to those by which Hemoglobin (Hb) releases oxygen (O2), no serious attempts have been made to correlate the oxygen delivery capacity of PFCs to those of Hb. This paper presents theoretical ways in which this can be done and demonstrates that a 2.7 g/kg dose of PFC is approximately equivalent to 4 g/dL [Hb]. Clinical trial planning is discussed.
KeywordsDioxide Bromide Carbon Monoxide Fluorocarbon Perflubron
Unable to display preview. Download preview PDF.
- 1.Gregory IC. The oxygen and carbon monoxide capacities of foetal and adult blood. J Physiol 1974;326:625–634.Google Scholar
- 2.Braunitzer G. Molekulaire struktur von haemoglobine. Nova Acta Acad Caesar Leop Carat 1963;26:471.Google Scholar
- 4.Geyer RP, Monroe RG, Taylor K. Survival of rats totally perfused with a fluorocarbon-detergent preparation. In: Normal JC Ed. Organ perfusion and preservation. New York:Appleton Century Crofts 1986;85–96.Google Scholar
- 8.Batra S, Peters BP, Symonds JD, et al. Perflubron emulsion increases tissue oxygenation in a canine model of hemodilution. Artif Cells, Blood Subs and Immob Technol 1996;24:307.Google Scholar
- 11.Spahn DR, Waschke K, Standl T, et al. Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European Phase 3 study. Anesthes 2002;97. In Press.Google Scholar
- 12.Turnan KJ. Tissue oxygen delivery. Anesthesiology Clinics of North America 1990;8:451–69.Google Scholar