Abstract
A typical tumor releases angiogenesis factor that induces the capillary growth around the tumor and, therefore, a greater amount of blood is present around the tumor. A tumor usually, therefore, becomes a local absorber due to its higher hemoglobin concentration. The ultimate goal of this project is to localize the position of a tumor in a breast tissue at an early stage using near infrared spectroscopy.
Computer simulations were performed to obtain TRS spectra at various locations in a system with optical properties of human breast. The time domain output pulses, then, were transferred to the frequency domain and the data were analyzed at various modulated frequencies. The changes in the photon path with respect to the frequency were systematically studied for absorber localization in three-dimensions.
Two different source-detector configurations, transmittance and reflectance were studied to explore the best TRS spectra acquisition procedure for tumor localization. Our previous study results have shown that in reflectance measurements the photon penetration depth is dependent on both the source-detector (S-D) separation distance and the modulation frequency. More specifically, the photon penetration depth decreases at smaller source and detector separations and higher frequencies. In this study, the effects of these two parameters on the photon path were studied in both transmittance and reflectance. This study results may be used effectively in determining the position.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Abbreviations
- NIR-TRS:
-
Near infrared time resolved spectroscopy
- S-D:
-
Source and detector
- MR:
-
Magnitude ratio
- ⌽:
-
phase
References
Creasey WA. Tumor angiogenesis. The growth of tumors:Growth of tumor masses. New York: Oxford, 1981; 60–62.
Hemelt MW, Barnett JT, Bruley DF, Kang KA. Two and three dimensional localization of deep vein thrombosis using near infrared time resolved spectroscopy. Proc 1997 south biomed eng conf. 1997;449–454.
Kang KA, Bruley DF, Londono JM, Chance B. Highly scattering optical system identification via frequency response analysis of optical NIR-TRS spectra. Ann Biomed eng 1994;22:240–252.
Hemelt MW, Barnett JT, Bruley DF, Kang KA. The application of NIR-TRS and frequency response analysis for deep vein thrombosis detection. Biotechnol Prog 1997; 13: 640–648.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Honar, A.L., Ricks, C., Kang, K.A. (2003). Preliminary Studies on the Photon Path in Breast Tissue Model by NIR-TRS. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_11
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0075-9_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4912-9
Online ISBN: 978-1-4615-0075-9
eBook Packages: Springer Book Archive