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Marrow Stromal Cells (MSC): A species Comparison

  • Anthony Kicic
  • Adam C. Shanley
  • Christine M. Hall
  • P. Elizabeth Rakoczy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 533)

Abstract

Retinal degenerations and dystrophies are the major causes of inherited blindness in the developed world comprising a variety of disparate genetically determined conditions that differ from one another in their mode of inheritance, severity, topographic pattern of visual loss, and ophthalmoscopic appearance. Onset of most genetically inherited retinal degenerations and dystrophies usually occurs early-on in life, and thus they have a great socio-economic impact on the community. Since these retinal disorders are phenotypically heterogeneous, early clinical and molecular diagnosis is rare and as a result, no treatment methods currently exist for these conditions. Histologically, they are characterized by the apoptotic death of one subset of cells in the retina, namely the photoreceptors (Lolley et al., 1994). However, some function may still exist in the remaining retina and in the axons connecting the retina to the brain. Hence photoreceptor replacement as part of a gene or cell-based therapy may aid in the restoration of some degree of vision (Ali et al., 2000).

Keywords

Retinal Degeneration Species Comparison Retinal Progenitor Corneal Neovascularization Human Bone Marrow Stromal Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Anthony Kicic
    • 1
  • Adam C. Shanley
    • 1
    • 2
  • Christine M. Hall
    • 1
    • 2
  • P. Elizabeth Rakoczy
    • 2
  1. 1.Stem Cell Unit, Department of Molecular OphthalmologyLions Eye Institute affiliated with the Centre of Ophthalmology and Visual Science, University of Western AustraliaNedlandsAustralia
  2. 2.Centre of Ophthalmology and Visual ScienceThe University of Western AustraliaNedlandsAustralia

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