Streptozotocin-Induced Diabetes — A Rat Model to Study Involvement of Retinal Cell Types in the Onset of Diabetic Retinopathy
Diabetic retinopathy (DR) is a potentially blinding complication of diabetes mellitus. After the initial diagnosis of diabetes, the deficiencies typical for DR, namely abnormal autoregulation of retinal arteries, increased blood flow, breakdown of the blood-retinal barrier, and disturbances in retinal function develop silently and remain clinically undetected for quite some time. A characteristic microangiopathy in the fundus is one of the first visible signs of DR. Macular edema, neovascularization, contraction of the vitreous and of proliferated fibrovascular tissue are late consequences in the diabetic eye. The severity of these lesions is closely related to the duration of diabetes, to blood glucose control, and to risk factors such as hypertension.
KeywordsVascular Endothelial Growth Factor Diabetic Retinopathy Retinal Pigment Epithelium Proliferative Diabetic Retinopathy Evans Blue
Unable to display preview. Download preview PDF.
- Ambati, J., Chalam, K., Chawla, D., D’Angio, C., Guillet, E., Rose, S., Vanderlinde, R., and Ambati, B., 1997, Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy.Arch. Ophthalmol. 115:1161.PubMedCrossRefGoogle Scholar
- Bok, D., Senanayake, P., Calabro, A., Hu, J.G., and Hollyfield, J.G., 2002, Glycogen synthesis in human RPE. Invest. Ophthalmol. Vis. Sci. ARVO no. 4569 43:182.Google Scholar
- Miyamoto, K., Khosrof, S., Bursell, S.-E., Rohan, R., Murata, T., Clermont, A.C., Aiello, L.P., Ogura, Y., and Adamis, A.O., 1999, Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.Proc. Natl. Acad. Sci. 96:10836.PubMedCrossRefGoogle Scholar