Streptozotocin-Induced Diabetes — A Rat Model to Study Involvement of Retinal Cell Types in the Onset of Diabetic Retinopathy

  • Elisabeth Rungger-Brändle
  • André A. Dosso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 533)


Diabetic retinopathy (DR) is a potentially blinding complication of diabetes mellitus. After the initial diagnosis of diabetes, the deficiencies typical for DR, namely abnormal autoregulation of retinal arteries, increased blood flow, breakdown of the blood-retinal barrier, and disturbances in retinal function develop silently and remain clinically undetected for quite some time. A characteristic microangiopathy in the fundus is one of the first visible signs of DR. Macular edema, neovascularization, contraction of the vitreous and of proliferated fibrovascular tissue are late consequences in the diabetic eye. The severity of these lesions is closely related to the duration of diabetes, to blood glucose control, and to risk factors such as hypertension.


Vascular Endothelial Growth Factor Diabetic Retinopathy Retinal Pigment Epithelium Proliferative Diabetic Retinopathy Evans Blue 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Elisabeth Rungger-Brändle
    • 1
  • André A. Dosso
    • 1
  1. 1.Cell Biology LaboratoryUniversity Eye ClinicGeneva 14Switzerland

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