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In Vivo EPR (ESR) pp 515–545Cite as

Pharmaceutical Applications of In Vivo EPR

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Part of the book series: Biological Magnetic Resonance ((BIMR,volume 18))

Abstract

This chapter illustrates the potential of In vivo EPR in several areas of pharmaceutical sciences: pharmaceutical technology, pharmacodynamics, toxicology, and pharmacokinetics. This method offers unique opportunities to characterise delivery processes. It provides information about the microenvironment inside the drug carriers (microviscosity, micropolarity, microacidity) and permits the quantitative characterisation of release mechanisms. Localised information can be obtained by means of different nitroxide isotopes or by EPR imaging. Gamma sterilisation derived radicals may serve as endogenous signals to monitor water penetration in clinically used drug carriers. EPR is capable to characterise metabolic processes and to follow the pharmacokinetics of nitroxides and metal ions noninvasively in vivo. Pharmacodynamic applications are related to the measurements of the oxygen level, the microacidity and the level of nitric oxide.

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  1. Karsten Mäder

    Present address: Institute of Pharmaceutics & Biopharmacy, Martin-Luther-University, Halle, Germany

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Free University, Berlin, Germany

    Karsten Mäder & Bernard Gallez

  2. Laboratory of Medicinal Chemistry and Radiopharmacy, Laboratory of Biomedical Magnetic Resonance, Université Catholique de Louvain, Brussels, Belgium

    Karsten Mäder & Bernard Gallez

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  1. Karsten Mäder
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  2. Bernard Gallez
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  1. University of Denver, Denver, Colorado, USA

    Lawrence J. Berliner

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Mäder, K., Gallez, B. (2003). Pharmaceutical Applications of In Vivo EPR. In: Berliner, L.J. (eds) In Vivo EPR (ESR). Biological Magnetic Resonance, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0061-2_19

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