Molecular Basis of Antimalarial Drug Resistance in Indonesia

  • Din Syafruddin
  • Puji B. S. Asih
  • Josephine E. Siregar
  • Emiliana Tjitra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 531)


Malaria continues to be a major public health problem in Indonesia. In fact over 3 million clinical cases of malaria and about 100 deaths are reported annually through hospitals and public health centres (Ministry of Health, The Republic of Indonesia, compiled data, 1998). The spread of drug-resistant parasites and the recent outbreaks and re-emergence of malaria in places previously declared malaria-free have forced the Government of Indonesia to re-assess the current national malaria control strategy. In 1998, it was reported that 46.2% of the total Indonesian population (210.6 million individuals) were settled in malaria-endemic areas and among these, 56.3 million were living in moderate-to high-risk areas. Of the 3.33 million clinically suspected malaria cases, 196,332 were laboratory-confirmed and 20% were from Java and Bali. The remaining cases were reported from the outer islands.


Plasmodium Falciparum Mutant Allele Antimalarial Drug Dihydrofolate Reductase Chloroquine Resistance 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Din Syafruddin
    • 1
    • 3
  • Puji B. S. Asih
    • 1
  • Josephine E. Siregar
    • 1
  • Emiliana Tjitra
    • 2
  1. 1.Eijkman Institute for Molecular BiologyJakarta
  2. 2.National Institute of Health Research and Development, The Ministry of HealthJakarta
  3. 3.Department of Parasitology, Faculty of MedicineHasanuddin UniversityMakassarIndonesia

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