Abstract
Despite more than 100 years of intense scientific and clinical study, malaria is currently the second highest communicable cause of global mortality (www.who.int/inf-fs/en/fact094.html). Myriad clinical, socioeconomic and political factors contribute to this statistic. Parasitic resistance to antimalarials represents one critical factor, and although new and effective pharmaceuticals are available, they are prohibitively expensive for many malaria-susceptible communities. In the geographical regions most affected by malaria (sub-Saharan Africa, tropical Asia, and South America), access to adequate health care is also often severely limited. Moreover, poor nutrition or other endemic infectious diseases may exacerbate the risk of severe malaria.
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Keenihan, S.H. et al. (2003). Plasmodium Falciparum. In: Marzuki, S., Verhoef, J., Snippe, H. (eds) Tropical Diseases. Advances in Experimental Medicine and Biology, vol 531. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0059-9_7
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