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Micronutrient Deficiency and Supplementation in Indonesian Infants

Interactions between micronutrients
  • Marjoleine A. Dijkhuizen
  • Frank T. Wieringa
  • Clive E. West
  • Muhilal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 531)

Abstract

“Micronutrients” is the collective term used to describe vitamins and trace elements, both of which are required in only small amounts by the body. Vitamins may be present in the diet as such or derived from pro-vitamins. Foods, for instance, can contain vitamin A either as retinol or as pro-vitamin A carotenoids from which vitamin A can be formed. 13-Carotene is the most important pro-vitamin A in the human diet. Vitamins and trace elements such as iron, zinc, and copper serve many metabolic functions, often as part of protein complexes like in haemoglobin and metalloenzymes.

Keywords

Zinc Deficiency Iron Supplementation Retinol Binding Protein Micronutrient Deficiency Plasma Vitamin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baly, D.L., Golub, M.S., Gershwin, M.E., and Hurley, L.S., 1984, Studies of marginal zinc deprivation in rhesus monkeys. III. Effects on vitamin A metabolism. Am. J. Clin. Nutr. 40 199–207.PubMedGoogle Scholar
  2. Beaton, G.H., Martorell, R., L’Abbe, K.A., Edmonston, B., McCabe, G.P., Ross, A.C., and Harvey, B., 1992, Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. Final report to CIDA. University of Toronto, Canada.Google Scholar
  3. Bhutta, Z.A., Bird, S.M., Black, R.E., Brown, K.H., Meeks Gardner, J., Hidayat, A., Khatun, F., Martorell, R., Ninh, N.X., Penny, M.E., Rosado, J.L., Roy, S.K., Ruel, M., Sazawal, S., and Shankar, A.H., 2000, Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. Am. J. Clin. Nutr. 72 1516–1522.PubMedGoogle Scholar
  4. Castenmiller, J.J. and West, C.E., 1998, Bioavailability and bioconversion of carotenoids. Annu. Rev. Nutr. 18 19–38.PubMedCrossRefGoogle Scholar
  5. Dijkhuizen, M.A., Wieringa, F.T., West, C.E., Muherdiyantiningsih, and Muhilal., 200la, Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia. Am. J. Clin. Nutr. 73786–791.Google Scholar
  6. Dijkhuizen, M.A., Wieringa, F.T., West, C.E., Sri Martuti, and Muhilal, 2001b, Effects of iron and zinc supplementation in Indonesian infants on micronutrient status and growth. J. Nutr. 131 2860–2865.Google Scholar
  7. Ferguson, E.L., Gibson, R.S., Opare-Obisaw, C., Ounpuu, S., Thompson, L.U., and Lehrfeld, J., 1993, The zinc nutriture of preschool children living in two African countries. J. Nutr. 123 1487–1496.PubMedGoogle Scholar
  8. Goldenberg, R.L., Tamura, T., Neggers, Y., Copper, R.L., Johnston, K.E., DuBard, M.B., and Hauth, J.C., 1995, The effect of zinc supplementation on pregnancy outcome. JAMA 274 463–468.PubMedCrossRefGoogle Scholar
  9. Gunshin, H., MacKenzie, B., and Berger, U.V., 1997, Cloning and characterization of a mammalian proton-coupled metal-ion transported. Nature 1997 388 482–488.PubMedCrossRefGoogle Scholar
  10. Hallberg, L., Brune, M., Erlandsson, M., Sandberg, A.S., and Rossander-Hulten, L., 1991,Calcium: effect of different amounts on nonheme and heme-iron absorption in humans.Am. J. Clin. Nutr. 53 112–119PubMedGoogle Scholar
  11. Morrison, S.A., Russell, R.M., Carney, E.A., and Oaks, E.V., 1978, Zinc deficiency: a cause of abnormal dark adaptation in cirrhotics. Am. J. Clin. Nutr. 31: 276–281.PubMedGoogle Scholar
  12. Rahman, M.M., Wahed, M.A., Fuchs, G.J., Baqui, A.H., and Alvarez, J.O., 2002, Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children. Am. J. Clin. Nutr. 75: 92–98.PubMedGoogle Scholar
  13. Roodenburg, A.J.C., West, C.E., Yu, S., and Beynen, A.C., 1994, Comparison between time-dependent changes in iron metabolism of rats as induced by marginal deficiency of either vitamin A or iron. Br. J. Nutr. 71: 687–699.PubMedCrossRefGoogle Scholar
  14. Sommer, A., Tarwotjo, I., Djunaedi, E., West, K.P., Jr., Loeden, A.A., Tilden, R., Mele, L., and ACEH Study Group, 1986, Impact of vitamin A supplementation on childhood mortality: a randomised controlled community trial. Lancet 1169–1173.Google Scholar
  15. Suhamo, D., West, C.E., Muhilal, Karyadi, D., and Hautvast, J.G., 1993, Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 342 1325–1328.Google Scholar
  16. Tanumihardjo, S.A., Cheng, J.C., Permaesih, D., Muherdiyantiningsih, Rustan, E., Muhilal, Karyadi, D., and Olson, J.A., 1996, Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children. Am. J. Clin. Nutr. 64 966–971.PubMedGoogle Scholar
  17. Tomkins, A., 2000, Malnutrition, morbidity and mortality in children and their mothers. Proc. Nutr. Soc. 59 135–146.PubMedCrossRefGoogle Scholar
  18. UNICEF-WHO Joint Committee on Health Policy, 1994, World summit for children: strategic approach to operationalizing selected end-decade goals; reduction of iron deficiency anaemia. Thirtieth Session. WHO, Geneva.Google Scholar
  19. West, K.P., Jr., Pokhrel, R.P., Katz, J., LeClerq, S.C., Khatry, S.K., Shrestha, S.R., Pradhan, E.K., Tielsch, J.M., Pandey, M.R., and Sommer, A., 1991, Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet 338 67–71.PubMedCrossRefGoogle Scholar
  20. Whittaker, P., 1998, Iron and zinc interactions in humans. Am. J. Clin. Nutr. 68 442S–446S.PubMedGoogle Scholar
  21. Wood, R.J., and Zheng, J.J., 1997, High dietary calcium intakes reduce zinc absorption and balance in humans. Am. J. Clin. Nutr. 65 1803–1809.PubMedGoogle Scholar
  22. Wieringa, F.T., Dijkhuizen, M.A., West, C.E., Thumham, D.I., Mulihal, and Van der Meer, J.W.M, 2003, Redistribution of vitamin A after iron supplementation in Indonesian Infants. Am J Clin Nutr. 77 651–657PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Marjoleine A. Dijkhuizen
    • 1
    • 2
    • 3
    • 4
  • Frank T. Wieringa
    • 1
    • 2
    • 3
  • Clive E. West
    • 1
  • Muhilal
    • 3
  1. 1.Department of Human Nutrition and EpidemiologyWageningen UniversityThe Netherlands
  2. 2.Department of Internal MedicineUniversity Medical Center NijmegenThe Netherlands
  3. 3.Department Biology and SocietyVrije UniversityAmsterdamThe Netherlands
  4. 4.Nutrition Research and Developmental CenterBogorIndonesia

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