A Vaccine for Nontypable Haemophilus influenzae

  • Allan W. Cripps
  • Jennelle M. Kyd
Part of the Medical Intelligence Unit book series (MIUN)


Nontypable H. influenzae (NTHI) is a common commensal of the upper respiratory tract residing in both the nasopharynx and the posterior oropharynx. It is one of the leading causative bacterial pathogens of otitis media (OM) in children and serious urogenital, neonatal and mother-infant infections. It is also the cause of significant morbidity in patients with pulmonary diseases such as cystic fibrosis and chronic obstructive pulmonary disease. NTHI colonizes the respiratory tract through adherence to the mucous and epithelial cells. It has several bacterial surface components that have the capacity to facilitate adherence and interactions between the bacterium and epithelial cells, setting the stage for the cycle of inflammation. Whole killed cell or bacterial extracts have been investigated in human trials providing results that demonstrate the potential for a vaccine to protect against infection. Several lead candidate antigens have been proposed based on studies in animal models but have yet to be formulated for human trials. The composition of a vaccine requires that the antigens be conserved among strains, immunogenic and protective against infection and that the delivery of the vaccine results in the relevant immune response, probably a balance of specific cellular and humoral responses.


Chronic Obstructive Pulmonary Disease Chronic Bronchitis Haemophilus Influenzae Outer Membrane Protein Acute Bronchitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Allan W. Cripps
  • Jennelle M. Kyd

There are no affiliations available

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