Skip to main content

Functional Proteins and Peptides from Fish Skin

  • Chapter
  • First Online:
Seafood Processing By-Products

Abstract

Seafood processing gives rise to a large volume of by-products all over the world. However, due to environmental and legislative issues regarding the disposal of these by-products, various other means of utilizing them are being researched. Among them, conversion of these waste materials into value-added functional materials is a promising approach. Fish skin discarded as a processing by-product of filleting accounts for around 30 % of the fish processing waste. The discarded fish skin is a favorable source to extract collagen and gelatin. These fish proteins could be developed to give advanced functional activities over their routine nutritional benefits to enhance human health. Moreover, the hydrolysates and peptides extracted from these protein sources have shown potent biological activities against hypertension and oxidative stress. This chapter gives a brief insight into the functionality of the proteins and peptides isolated from fish skin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aberoumand A (2010) Isolation and characteristics of collagen from fish waste material. World J Fish Mar Sci 2:471–474

    Google Scholar 

  • Ahmad M, Benjakul S, Prodpran T, Agustini TW (2012) Physico-mechanical and antimicrobial properties of gelatin film from the skin of unicorn leatherjacket incorporated with essential oils. Food Hydrocol 28:189–199

    Article  CAS  Google Scholar 

  • Balti R, Bougatef A, Ali NE-H, Zekri D, Barkia A, Nasri M (2010) Influence of degree of hydrolysis on functional properties and angiotensin I-converting enzyme-inhibitory activity of protein hydrolysates from cuttlefish (Sepia officinalis) by-products. J Sci Food Agr 90:2006–2014

    CAS  Google Scholar 

  • Bhaskar N, Benila T, Radha C, Lalitha RG (2008) Optimization of enzymatic hydrolysis of visceral waste proteins of Catla (Catla catla) for preparing protein hydrolysate using a commercial protease. Bioresour Technol 99:335–343

    Article  CAS  Google Scholar 

  • Byun H-G, Kim S-K (2001) Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin. Process Biochem 36:1155–1162

    Article  CAS  Google Scholar 

  • Cudennec B, Fouchereau-Peron MF, Ferry F, Duclos E, Ravallec R (2012) In vitro and in vivo evidence for a satiating effect of fish protein hydrolysate obtained from blue whiting (Micromesistius poutassou) muscle. J Funct Foods 4:271–277

    Article  CAS  Google Scholar 

  • Cushman DW, Cheung HS (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20:1637–1648

    Article  CAS  Google Scholar 

  • Erdmann K, Cheung BWY, Schröder H (2008) The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease. J Nutr Biochem 19:643–654

    Article  CAS  Google Scholar 

  • Gómez-Guillén MC, Giménez B, López-Caballero ME, Montero MP (2011) Functional and bioactive properties of collagen and gelatin from alternative sources: a review. Food Hydrocol 25:1813–1827

    Article  CAS  Google Scholar 

  • Harnedy PA, FitzGerald RJ (2012) Bioactive peptides from marine processing waste and shellfish: a review. J Funct Food 4:6–24

    Article  CAS  Google Scholar 

  • Himaya SWA, Ngo DH, Ryu B, Kim SK (2012a) An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress. Food Chem 132:1872–1882

    Article  CAS  Google Scholar 

  • Himaya SWA, Ryu B, Ngo DH, Kim SK (2012b) Peptide isolated from Japanese flounder skin gelatin protects against cellular oxidative damage. J Agr Food Chem 60:9112–9119

    Article  CAS  Google Scholar 

  • Hsu KC (2010) Purification of antioxidative peptides prepared from enzymatic hydrolysates of tuna dark muscle by-product. Food Chem 122:42–48

    Article  CAS  Google Scholar 

  • Huang R, Mendis E, Kim S-K (2005) Improvement of ACE inhibitory activity of chitooligosaccharides (COS) by carboxyl modification. Bioorg Med Chem 13:3649–3655

    Article  CAS  Google Scholar 

  • Jamilah B, Tan KW, Umi Hartina MR, Azizah A (2011) Gelatins from three cultured freshwater fish skins obtained by liming process. Food Hydrocol 25:1256–1260

    Article  CAS  Google Scholar 

  • Jeon Y-J, Byun H-G, Kim S-K (1999) Improvement of functional properties of cod frame protein hydrolysates using ultrafiltration membranes. Process Biochem 35:471–478

    Article  Google Scholar 

  • Kato S, Matsui H, Saitoh Y, Miwa N (2011) Fish collagen-containing drink is subcutaneously absorbed and attenuates the UVA-induced tissue-integrity destruction and DNA damages in 3D-human skin tissue model. J Funct Food 3:50–55

    Article  CAS  Google Scholar 

  • Khantaphant S, Benjakul S, Ghomi MR (2011) The effects of pretreatments on antioxidative activities of protein hydrolysate from the muscle of brownstripe red snapper (Lutjanus vitta). LWT Food Sci Technol 44:1139–1148

    Article  CAS  Google Scholar 

  • Kim S-K, Mendis E (2006) Bioactive compounds from marine processing byproducts – a review. Food Res Int 39:383–393

    Article  CAS  Google Scholar 

  • Kim S-K, Kim Y-T, Byun H-G, Nam K-S, Joo D-S, Shahidi F (2001) Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska pollack skin. J Agric Food Chem 49:1984–1989

    Article  CAS  Google Scholar 

  • Kim S-Y, Je J-Y, Kim S-K (2007) Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion. J Nutr Biochem 18:31–38

    Article  CAS  Google Scholar 

  • Kristinsson HG, Rasco BA (2000) Fish protein hydrolysates: production, biochemical, and functional properties. Crit Rev Food Sci Nutr 40:43–81

    Article  CAS  Google Scholar 

  • Lee S-H, Qian Z-J, Kim S-K (2010) A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Food Chem 118:96–102

    Article  CAS  Google Scholar 

  • Lee CM, Barrow CJ, Kim S-K, Miyashita K, Shahidi F (2011) Global trends in marine nutraceuticals. Food Technol 65:22–31

    CAS  Google Scholar 

  • Li XX, Han LJ, Chen LJ (2008) In vitro antioxidant activity of protein hydrolysates prepared from corn gluten meal. J Sci Food Agr 88:1660–1666

    Article  CAS  Google Scholar 

  • Meisel H (1997) Biochemical properties of regulatory peptides derived from milk proteins. Biopolymers 43:119–128

    Article  CAS  Google Scholar 

  • Mendis E, Rajapakse N, Byun H-G, Kim S-K (2005) Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their in vitro antioxidant effects. Life Sci 77:2166–2178

    Article  CAS  Google Scholar 

  • Moskowitz RW (2000) Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum 30:87–99

    Article  CAS  Google Scholar 

  • Nalinanon S, Benjakul S, Kishimura H, Shahidi F (2011) Functionalities and antioxidant properties of protein hydrolysates from the muscle of ornate threadfin bream treated with pepsin from skipjack tuna. Food Chem 124:1354–1362

    Article  CAS  Google Scholar 

  • Ngo D-H, Qian Z-J, Ryu BM, Park JW, Kim S-K (2010) In vitro antioxidant activity of a peptide isolated from Nile tilapia (Oreochromis niloticus) scale gelatin in free radical-mediated oxidative systems. J Funct Food 2:107–117

    Article  CAS  Google Scholar 

  • Ngo D-H, Ryu BM, Vo T-S, Himaya SWA, Wijesekara I, Kim S-K (2011) Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin. Int J Biol Macromol 49:1110–1116

    Article  CAS  Google Scholar 

  • Pati F, Adhikari B, Dhara S (2010) Isolation and characterization of fish scale collagen of higher thermal stability. Bioresour Technol 101:3737–3742

    Article  CAS  Google Scholar 

  • Pei X, Yang R, Zhang Z, Gao L, Wang J, Xu Y, Zhao M, Han X, Liu Z, Li Y (2010) Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice. Food Chem 118:333–340

    Article  CAS  Google Scholar 

  • Perera MR, Bardeesy N (2011) Cancer: when antioxidants are bad. Nature 475:43–44

    Article  CAS  Google Scholar 

  • Picot L, Bordenave S, Didelot S, Fruitier-Arnaudin I, Sannier F, Thorkelsson G, Bergé JP, Guérard F, Chabeaud A, Piot JM (2006) Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines. Process Biochem 41:1217–1222

    Article  CAS  Google Scholar 

  • Qian Z-J, Jung W-K, Lee S-H, Byun H-G, Kim S-K (2007) Antihypertensive effect of an angiotensin I-converting enzyme inhibitory peptide from bullfrog (Rana catesbeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochem 42:1443–1448

    Article  CAS  Google Scholar 

  • Rajapakse N, Jung W-K, Mendis E, Moon S-H, Kim S-K (2005) A novel anticoagulant purified from fish protein hydrolysate inhibits factor XIIa and platelet aggregation. Life Sci 76:2607–2619

    Article  CAS  Google Scholar 

  • Ranathunga S, Rajapakse N, Kim S-K (2006) Purification and characterization of antioxidative peptide derived from muscle of conger eel (Conger myriaster). Eur Food Res Technol 222:310–315

    Article  CAS  Google Scholar 

  • Samaranayaka AGP, Li-Chan ECY (2008) Autolysis-assisted production of fish protein hydrolysates with antioxidant properties from Pacific hake (Merluccius productus). Food Chem 107:768–776

    Article  CAS  Google Scholar 

  • Senaratne LS, Park P-J, Kim S-K (2006) Isolation and characterization of collagen from brown backed toadfish (Lagocephalus gloveri) skin. Bioresour Technol 97:191–197

    Article  CAS  Google Scholar 

  • Thiansilakul Y, Benjakul S, Shahidi F (2007) Compositions, functional properties and antioxidative activity of protein hydrolysates prepared from round scad (Decapterus maruadsi). Food Chem 103:1385–1394

    Article  CAS  Google Scholar 

  • Wilson J, Hayes M, Carney B (2011) Angiotensin-I-converting enzyme and prolyl endopeptidase inhibitory peptides from natural sources with a focus on marine processing by-products. Food Chem 129:235–244

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Se-Kwon Kim .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Himaya, S.W.A., Kim, SK. (2014). Functional Proteins and Peptides from Fish Skin. In: Kim, SK. (eds) Seafood Processing By-Products. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9590-1_11

Download citation

Publish with us

Policies and ethics