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Adult Lung Stem Cells

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Adult Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Over the past decade a wealth of information has been divulged on stem cells present in the lung both in the pulmonary vasculature and the respiratory tract. Cells have been identified with the capability of repopulating the lung and others that contribute to the pathogenesis or, conversely, have therapeutic benefit in pulmonary vascular disease. The isolation of a single-resident lung stem cell capable of repopulating any lung epithelium still remains elusive. What is currently known about stem and progenitor cells in the lung suggests that a non-classical stem cell hierarchy exists with a novel array of cellular mechanisms controlling proliferation and differentiation of such cells. This chapter serves to provide an up-to-date review of what is currently known about stem and progenitor cells within the lung.

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Abbreviations

5-HT2B :

5-hydroxytryptamine receptor 2B

ATI/ATII:

Alveolar type I and type II cells

BADJ:

Bronchoalveolar duct junction

BASC:

Bronchiolar stem cell

BMP:

Bone morphogenic protein

CCSP:

Clara cell secretory protein (also CC10)

CGRP:

Calcitonin gene-related peptide

COPD:

Chronic obstructive pulmonary disease

CTEPH:

Chronic thromboembolic pulmonary hypertension

CXCR4:

c-x-c chemokine receptor 4

EGF/EGFR:

Epidermal growth factor/epidermal growth factor receptor

EMT:

Epithelial mesenchymal transition

EndMT:

Endothelial mesenchymal transition

eNOS:

Endothelial nitric oxide synthase

EPC:

Endothelial progenitor cell

FGF:

Fibroblast growth factor

FOXA2:

Forkhead box protein A2

FOXJ1:

Forkhead box protein J1

HSC:

Hematopoietic stem cell

IL-13:

Interleukin 13

IPF:

Idiopathic pulmonary fibrosis

Krt:

Cytokeratin

LDL:

Acetylated low density lipoprotein

MSC/MPC:

Mesenchymal stem/progenitor cell

NEB:

Neuroepithelial body

OVA:

Ovalbumin

PH:

Pulmonary hypertension

PNE/PNEB:

Pulmonary neuroendocrine cells/bodies

PO2 :

Partial pressure of oxygen

RA:

Retinoic acid

SCGB1A1:

Secretoglobin, family 1A, member 1 (uteroglobin)

SDF-1:

Stromal-derived factor 1

Shh:

Sonic hedgehog

SOX2:

SRY (sex-determining region Y)-box 2

SPA/B/C/D:

Surfactant protein A/B/C/D

TGF-β:

Transforming growth factor beta

TNF-α:

Tumor necrosis factor alpha

TTF-1:

Thyroid transcription factor 1

VEGFR2:

Vascular endothelial growth factor receptor 2

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Authors and Affiliations

  1. Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Amy L. Firth

  2. Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, 60612, USA

    Ruby A. Fernandez

  3. Department of Medicine, University of Illinois at Chicago, COMRB 3131 (MC 719), 909 S. Wolcott Ave., Chicago, IL, 60612, USA

    Jason X.-J. Yuan M.D., Ph.D.

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  1. Amy L. Firth
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  2. Ruby A. Fernandez
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  3. Jason X.-J. Yuan M.D., Ph.D.
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Correspondence to Amy L. Firth or Jason X.-J. Yuan M.D., Ph.D. .

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  1. Regenerative Medicine Program, Ottawa Hospital Research Institute Sprott Centre for Stem Cell Research, Ottawa, Ontario, Canada

    Kursad Turksen

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Firth, A.L., Fernandez, R.A., Yuan, J.XJ. (2014). Adult Lung Stem Cells. In: Turksen, K. (eds) Adult Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9569-7_12

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