New Theories and Their Clinical Relevance to the Onset and Development of Periodontal Diseases

Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Periodontal disease is one of the most prevalent diseases suffered by humans. The tooth loss damage does not produce mortality but the pathological mechanisms involved have common conditions with cardiovascular disease and diabetes, main causes of death in the developing countries. The cause of periodontal diseases is attributed to bacteria that form a microbial biofilm. Periodontitis has been shown to result from an imbalance among the natural microbial biofilm on the teeth, dental plaque, and the host inflammatory/immune response. Produce an irreversible alveolar bone resorption that leads to teeth loss. Nowadays the key question is why in some patients the inflammatory response to bacterial infections is limited to gingivitis and in others produces alveolar bone loss periodontitis. Also, a small proportion of subjects exhibit severe and extensive periodontitis in any given age-group, but the proportion affected is greater in older age-groups. Therefore, our efforts should be to identify what are the characteristics of these patients to prevent and start the treatment as soon as possible. One of the possible mechanisms is an altered inflammatory response. We review new theories about inflammation and their clinical relevance to the onset and development of periodontal diseases, mainly at the cellular level. It has been highlighted the influence in the cellular response of the:
  1. (a)

    Biological/cell membrane and the lipid metabolism

  2. (b)

    Energy production process: mitochondria

  3. (c)

    Energy production control: AMPK system

  4. (d)

    Aggression recognition: inflammasome

  5. (e)

    Debris elimination: apoptosis/autophagy/hormesis


In this chapter we try to highlight the new theories and their clinical relevance to the onset and development of periodontal diseases that will change our way of managing our periodontal patients and should change the periodontal teaching in the future.


Lipid Raft Nicotinamide Adenine Dinucleotide Human Gingival Fibroblast Periodontitis Patient Regulate Energy Balance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Facultad de OdontologiaUniversidad de SevillaSevillaSpain

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