Reactive Oxygen Species and Antioxidant Systems in Periodontal Disease

Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Oxidative stress induced by reactive oxygen species (ROS) is thought to play a role in the pathogenesis of various age-related diseases, including periodontitis. Many reports have suggested that dietary antioxidant deficiency results in oxidative damage at the tissue level in association with periodontal disease. Furthermore, treatment with antioxidants has been shown to prevent pathophysiological changes associated with periodontal disease and promote functional recovery in in vitro studies, animal models, and clinical trials in humans. It is therefore possible that antioxidants could be successfully used in clinical practice for the treatment or prevention of ROS-related diseases such as periodontal disease. The development of potential therapeutic antioxidants for periodontal disease requires screening using direct methods for ROS detection and appropriate animal models.

Keywords

Superoxide Flavonoid Bilirubin Carotenoid Catalase 

Notes

Acknowledgments

This research was supported by a Grant-in-Aid for Scientific Research (no. 18592149 to M.L., no. 19592371 to T.K. & M.L., no. 23593049 to T.K., no. 23660047 to M.L.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Yokosuka-Shonan Disaster Health Emergency Research Center & ESR LaboratoriesKanagawa Dental UniversityYokosukaJapan

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