• Frederick D. Grant
  • Reid A. Maclellan
  • Arin K. Greene


The technique of lymphoscintigraphy images the lymphatic transit and lymph node accumulation of radiolabeled colloidal nanoparticles and is the first-line test to assess lymphatic function. It is used to diagnose lymphedema, a disease caused by either anomalous development of the lymphatic system or injury to lymphatic vasculature. Lymphoscintigraphy also can be used as a method of sentinel lymph node localization to aid in the staging of some cancers. In children and young adults, sentinel lymph node localization is used for a variety of tumors, including melanoma, rhabdomyosarcoma, and non-rhabdomyosarcoma soft tissue sarcomas, such as synovial cell sarcoma.


Sentinel Lymph Node Lymphatic Drainage Lymphatic Function Intradermal Injection Sentinel Lymph Node Mapping 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Frederick D. Grant
    • 1
    • 2
    • 3
  • Reid A. Maclellan
    • 4
  • Arin K. Greene
    • 5
  1. 1.Joint Program in Nuclear Medicine, Department of RadiologyHarvard Medical SchoolBostonUSA
  2. 2.Division of Nuclear Medicine and Molecular Imaging, Department of RadiologyBoston Children’s HospitalBostonUSA
  3. 3.Department of RadiologyBrigham and Women’s HospitalBostonUSA
  4. 4.Department of Plastic and Oral SurgeryBoston Children’s HospitalBostonUSA
  5. 5.Department of Plastic and Oral SurgeryBoston Children’s Hospital, Harvard Medical SchoolBostonUSA

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