Eligen® Technology for Oral Delivery of Proteins and Peptides

  • Sunita Prem Victor
  • Willi Paul
  • Chandra Prakash Sharma


The Eligen® technology, an oral delivery technology, is based on the design and development of proprietary delivery carriers referred to as Emisphere delivery agents. The major limitations for noninvasive delivery such as rapid metabolism, chemical instability, and minimal absorption through gastrointestinal (GI) tract are overcome by the application of these delivery agents. Most of the delivery agents consist of amino acids having a molecular weight of 250–300 Da that are structurally diverse with different physiochemical properties. They facilitate the absorption of macromolecules through a transcellular mechanism. These agents have been evaluated for their ability to enhance the delivery of a wide range of therapeutic macromolecules. This review discusses the major challenges and strategies employed to overcome these difficulties. It also focuses on the application of novel proprietary delivery agents that have enabled the oral delivery of a large number of therapeutic proteins and peptides.


Eligen® Macromolecules Absorption Transcellular Sodium N-[8-(2-hydroxybenzoyl)amino] caprylate (SNAC) Calcitonin Insulin Heparin Human growth hormone Vitamin B12 Parathyroid hormone 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Sunita Prem Victor
    • 1
  • Willi Paul
    • 1
  • Chandra Prakash Sharma
    • 1
  1. 1.Biomedical Technology WingSree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramIndia

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