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Vaginal Delivery of Biopharmaceuticals

Chapter

Abstract

The vagina may be an interesting alternative route for the delivery of biopharmaceuticals, particularly for the management of local conditions or the prevention of infection. The field of anti-HIV microbicides has been particularly prolific in the development of different active peptide/protein-based molecules, as well as of therapeutic genetic material, intended for vaginal administration. Alongside, vaginal vaccination has attracted considerable interest. However, the inherent features of the vaginal tract provide important hurdles to the optimized performance of active biomolecules and require rationale approaches toward the development of suitable products. This chapter provides an overview on such challenges and strategies adopted for the vaginal delivery of biopharmaceuticals.

Keywords

Vaginal drug delivery Microbicides siRNA Peptides Proteins Permeation enhancers Enzymatic inhibitors Nanocarriers Engineered microbiota 

Notes

Acknowledgments

This work was supported by Fundação para a Ciência e a Tecnologia, Portugal (grant VIH/SAU/0021/2011).

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.IINFACTS – Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da SaúdeInstituto Superior de Ciências da Saúde-Norte, CESPUGandraPortugal
  2. 2.Faculty of PharmacyUniversity of PortoPortoPortugal

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