Treatment of Brain Tumors

  • Betty M. Tyler
  • Gustavo Pradilla
  • Uri Hadelsberg
  • Hansen Bow
  • Ian Suk
  • Henry Brem
Chapter
Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

Malignant brain tumors are typically characterized by high rates of invasiveness and resistance to many forms of treatment. The main treatment modalities for malignant brain tumors consist of maximum safe surgical resection, chemotherapy, radiosurgery, or combination of these. Locally delivered chemotherapy is particularly suitable for brain tumor therapy following surgical resection since it bypasses the blood–brain barrier, maintains a higher stable drug concentration for longer periods of time, and has a more extensive distribution in the peritumoral areas than systemically administered chemotherapy with subsequent tumoricidal effects. The development of Gliadel, a BCNU-loaded polymer, approved in 1996 and successfully evaluated in clinical trials, has opened the door for a new arsenal of drugs for treatment of malignant primary brain tumors. New chemotherapeutic agents such as platinum-derived drugs, antiangiogenic compounds, and immunomodulatory molecules, among others, have undergone successful preclinical testing and await further clinical evaluation. A new generation of drug delivery microchips, gene-targeted drugs, and nanocarriers will enable simultaneous treatment with multiple agents based on the histological phenotype and genotype profile, which should result in highly individualized and more effective treatments for patients with this devastating disease.

Keywords

Placebo Catheter Enzymatic Degradation Paclitaxel Tamoxifen 

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Copyright information

© Controlled Release Society 2014

Authors and Affiliations

  • Betty M. Tyler
    • 1
  • Gustavo Pradilla
    • 1
  • Uri Hadelsberg
    • 2
  • Hansen Bow
    • 1
  • Ian Suk
    • 3
  • Henry Brem
    • 1
    • 4
    • 5
  1. 1.Department of Neurosurgery, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA
  2. 2.Technion-Israel Institute of TechnologyHaifaIsrael
  3. 3.Department of Neurosurgery, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA
  4. 4.Department of Oncology, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA
  5. 5.Department of BioMedical Engineering, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA

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