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Focal Controlled Drug Delivery pp 149–166Cite as

Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs

Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

In the past few decades significant progress has been made in development of drug delivery systems (DDSs) intended for targeted delivery of the drug to its site of action. Several dozens of systemically or focally administered DDSs have been approved for clinical use. However, the biofate of the drug/DDS following their administration is complex and is controllable only to a low extent. As a result, only low amounts of the drugs reach the target tissue, and the currently available DDSs are characterized by low clinical effectiveness and/or high magnitude of adverse effects. In this chapter, the major pharmacokinetic and pharmacodynamic parameters that govern the clinical effectiveness of systemically and focally administered DDSs are presented, and the ways to control the drug/DDSs disposition and to enhance the efficiency of the pharmacological responses are discussed. This chapter’s focus is on the anticancer DDSs for treatment of solid tumors and on the quantitative assessment of the analyzed factors/parameters.

Keywords

  • Drug Release
  • PBPK Model
  • Anticancer Treatment
  • Target Drug Delivery
  • Mononuclear Phagocyte System

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-1-4614-9434-8_6
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Fig. 6.1
Fig. 6.2
Fig. 6.3

Abbreviations

DDS:

Drug delivery system

EPR:

Enhanced permeability and retention effect

PBPK model:

Physiologically based pharmacokinetic model

PD:

Pharmacodynamics

PEG:

Polyethylene glycol

PK:

Pharmacokinetics

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Authors and Affiliations

  1. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 653, Beer-Sheva, 84105, Israel

    David Stepensky

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  1. David Stepensky
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Correspondence to David Stepensky .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Stepensky, D. (2014). Pharmacokinetic and Pharmacodynamic Aspects of Focal and Targeted Delivery of Drugs. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_6

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