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Vaginal Drug Delivery

Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

While the human vagina has great potential as an administration route for drug delivery, several challenges remain due to its variable nature and innate barriers. In this chapter, the distinctive barriers resulting from the anatomy and physiology of the vagina are presented. We then discuss strategies to rationally design vaginal drug delivery systems to maximize the efficacy and control the kinetics of drug delivery across the vaginal mucosa. The physical, rheological, and retentive properties of current vaginal dosage forms are compared as well as pharmacological considerations for vaginal delivery. Emerging nanomaterial strategies for vaginal drug delivery including nanoparticles and electrospun fibers are reviewed in depth, with a specific focus on HIV microbicide applications. The underlying principles for designing vaginal drug delivery systems that are discussed here have relevance for many reproductive health and mucosal delivery applications.

Keywords

  • Human Immunodeficiency Virus
  • Vaginal Delivery
  • Electrospun Fiber
  • Human Immunodeficiency Virus Prevention
  • PLGA Nanoparticles

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-1-4614-9434-8_27
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Fig. 27.1
Fig. 27.2
Fig. 27.3
Fig. 27.4

Abbreviations

ARV:

Antiretroviral

CAP:

Cellulose acetate phthalate

CTAB:

Cetyltrimethylammonium bromide

CVF:

Cervicovaginal fluid

EFV:

Efavirenz

FTC:

Emtricitabine

HAART:

Highly active antiretroviral therapy

HIV:

Human immunodeficiency virus

HSV-2:

Herpes simplex virus 2

IRV:

Intravaginal ring

nanoART:

Nano-antiretroviral therapy

NRTI:

Nucleotide reverse transcriptase inhibitor

PBMC:

Peripheral blood mononuclear cell

PCL:

Poly(caprolactone)

PDLLA:

Poly(d,l)-lactic acid

PEG:

Poly(ethylene glycol)

PEO:

Poly(ethylene oxide)

PLA:

Poly(lactic acid)

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly(l-lactic acid)

PPI:

Poly(propyleneimine)

PVA:

Poly(vinyl alcohol)

SHIV:

Simian-human immunodeficiency virus

SIV:

Simian immunodeficiency virus

SLS:

Sodium lauryl sulfate

SQV:

Saquinavir

STI:

Sexually transmitted infection

TDF:

Tenofovir disoproxil fumarate

TFV:

Tenofovir

VFS:

Vaginal fluid simulant

VP5k:

Vitamin E/5 kDa PEG

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Krogstad, E.A., Rathbone, M.J., Woodrow, K.A. (2014). Vaginal Drug Delivery. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_27

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